自体颅骨深低温保存再植的应用研究  

Transplantation of the cryopreserved skull bone autograft

作　　者：孙鹏[1] 孟庆海[1] 杨新生[1] 张文德[1] 兰小磊[1] 于新华[2] 李华建[2] 

机构地区：[1]青岛大学医学院附属医院神经外科,266003 [2]青岛大学医学院附属医院海阳分院

出　　处：《中华神经外科杂志》2009年第5期458-460,共3页Chinese Journal of Neurosurgery

摘　　要：目的研究深低温保存的颅骨瓣自体回植后的临床效果。方法颅脑创伤术后病人71例，高血压脑出血术后病人7例，脑肿瘤术后病人5例，脑动脉瘤术后病人3例，γ-刀术后去骨瓣减压病人3例。将手术取出的不带骨膜的游离骨瓣，经过处理后在深低温下保存，择期行骨瓣回植。结果所有病人均无排异反应和感染发生。79例顺利治愈，10例病人出现皮下积液，3例病人出现修补的颅骨凹陷。5例儿童病人术后骨愈合好，骨瓣与头颅同步增大，未出现颅骨发育异常。结论深低温保存的自体颅骨瓣原位回植可以在最大程度上接近正常颅骨，保持颅骨的各种功能。Objective This study examines the clinical effects of transplantation of the skull bone autograft after cryopreservation. Method The study group consisted of 89 patients. There are 51 cases males and 38 cases females in the group. 71 eranioeerebral injury ,7 hypertensive intracerebral hemorrhage ,5 brain turner, 3 aneurysm and 3 post 7-knife therapy patients. We preserved their skull bone flaps without periosteum at a low temperature and transplanted them back at a suitable time. Results None of the cases experienced rejection and infection. 79 cases were heal, subcutaneous effusion developed in 10 cases. Bone flaps were depressed in 3 and 3 cases who had seizure disorder prior to the repair improved after the surgery. In follow-up studies, all patients＇ skull curvature recovered well after the repair surgery. The resistance topressure locally at the repair site was very good. X-ray, CT and ECT studies also proved that all the flaps had healed well without any sign of necrosis. Conclusions The transplantation of a patient＇s own bone flap after eryopreservation is close to the normal skull and is superior to other material.

关 键 词：颅骨 低温保存 移植 

分 类 号：R686[医药卫生—骨科学]