不同部位动脉粥样硬化临床危险因素的相关性分析  

Clinical Risk Factors Related to Atherosclerosis at Different Sites

作　　者：曾佩[1] 何兆初[1] 区碧如[1] 曾昭华[1] 罗惠玲[1] 

机构地区：[1]广州医学院第一附属医院心内科,广东广州510120

出　　处：《广州医学院学报》2008年第6期15-18,共4页Academic Journal of Guangzhou Medical College

基　　金：广东省自然科学基金(00400870)

摘　　要：目的:分析患者不同部位动脉粥样硬化之间的关系,探讨各危险因素对不同部位的动脉作用是否不同。方法:收集本院心内科住院病人141例,所有患者冠状动脉行造影或CT检查,颈动脉和下肢动脉行彩色超声检查,根据影像学结果将入选病人分为4组:单纯下肢动脉疾病(PAD组)、单纯冠状动脉疾病(CAD组)、健康组、合并下肢动脉疾病和冠状动脉疾病(PAD+CAD组),了解4组之间在传统危险因素上的差别;比较颈动脉病变与下肢动脉病变在患病率上的不同。结果:PAD组中有吸烟史者多于CAD组(74.28%比51.28%,P<0.05);PAD+CAD组中有吸烟史者多于CAD组(75.00%比51.28%,P<0.05);颈动脉病变发生率较下肢动脉病变发生率高。结论:吸烟致下肢动脉疾病作用大于其对冠状动脉疾病作用;颈动脉检查对于动脉粥样硬化的早期检测可能更有价值。Objective： To investigate the correlation between arteries of different sites in the process of atheroselerosis, and to evaluate whether the risk factors contribute differently to lesions at varied sites. Methods： 141 hospitalized patients（ age 50 -80 years）were chosen and coronary angiography or 16-detector spiral CT was performed while giving color doppler ultrasonography check on carotid,lower extremity artery. Acording to the results of imaging, all patients were classified into four groups： simple peripheral disease group （PAD group） , simple coronary artery disease group（CAD group）, healthy group, combined peripheral disease and coronary artery disease（ PAD ＋ CAD group）, to investigate the difference in common risk factors across these groups, and to evaluate whether the incidence of atherosclerosis differs between carotid artery and lower extremity arteries. Results： There were more patients with a smoking history in the PAD group than in the CAD group（74.28% vs 51,28% ,P 〈0.05）, and in PAD ＋ CAD group than in CAD group （75.00% vs 51.28, P〈0.05 ）. Atherosclerosis was found to be more common in carotid artery than in arteries of lower extremities. Conclusion： Smoking may have a worse effect on peripheral than it does on coronary artery. Carotid artery detection might be more useful for？ early assessment of atheroselerosis.

关 键 词：吸烟 危险因素 动脉粥样硬化 下肢动脉疾病 冠状动脉疾病 颈动脉 

分 类 号：R543.5[医药卫生—心血管疾病]