国产洛伐他汀对高脂血症患者血脂代谢的影响  

Effects of Domestic Lovastatin on Lipid Metabolism in Patients With Hyperlipidemia

作　　者：周瑞海[1,2,3] 高海青 付绪杰[1,2,3] 蔡智荣 李秀琴 刘洪涛[1,2,3] 沃金善 陆廷菡[1,2,3] 刘向群[1,2,3] 赵长芹 郑发昌 

机构地区：[1]山东医科大学附属医院老年科 [2]中国人民解放军济南军区总医院 [3]青岛大学医学院附属医院

出　　处：《中国循环杂志》1998年第3期131-133,共3页Chinese Circulation Journal

摘　　要：目的：研究国产洛伐他汀对高脂血症患者血脂代谢的影响。方法：将１２０例患者随机分为洛伐他汀组（ｎ＝８０）及美降之组（ｎ＝４０），分别口服国产洛伐他汀及进口洛伐他汀（美降之），每次２０ｍｇ，每日２次，服用８周。观察用药４周及８周患者血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、（ＴＣ－ＨＤＬ－Ｃ）／ＨＤＬ－Ｃ、甘油三酯、载脂蛋白ＡⅠ（ＡｐｏＡⅠ）、载脂蛋白Ｂ１００（ＡｐｏＢ１００）及ＡｐｏＡⅠ／ＡｐｏＢ１００变化。结果：服用国产洛伐他汀４周及８周可分别使患者血清ＴＣ降低２３．０％及２７．３％，ＬＤＬ－Ｃ降低２７．９％及３４．１％，高甘油三酯血症患者甘油三酯水平降低２１．６％及２６．２％；ＨＤＬ－Ｃ升高９．１％及１０．１％，（ＴＣ－ＨＤＬ－Ｃ）／ＨＤＬ－Ｃ降低２９．６％及３７．１％。血清ＡｐｏＢ１００降低９．６％及１５．５％，ＡｐｏＡⅠ升高１８．９％及１４．５％，ＡｐｏＡⅠ／ＡｐｏＢ１００升高３９．９％及４４．９％。服药４周即有明显疗效。结论：国产洛伐他汀调血脂作用疗效肯定。Objective:To investigate the effects of domestic lovastatin on lipid metabolism of patients with hyperlipidemia. Methods:One hundred and twenty patients with hyperlipidemia were randomly assigned into lovastatin group ( n =80) and Mevacor group ( n =40).They were given domestic and imported lovastatin (Mevacor),respectively,20mg bid for 8 weeks.Serum total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol(HDL C),Apolipoprotein AⅠ(Apo AⅠ),Apolipoprotein B100(Apo B100) were measured at 4 and 8 weeks of the trial period.(TC-LDL C)/HDL C,Apo AⅠ/Apo B100 were calculated. Results:Four and 8 weeks after using domestic lovastatin,TC was decreased by 23 0% and 27 3%,respectively.In patients with hypertriglyceridemia,TG was decreased by 21 6% and 26 2%,LDL C by 27 9% and 34 1%,(TC-HDL C)/HDL C by 29 6% and 37 1%,while HDL C increased by 9 1% and 10 1%,respectively.Apo B100 was decreased by 9 6% and 15 5%,Apo AⅠ increased by 18 9% and 14 5%,and Apo AⅠ/Apo B100 increased by 39 9% and 44 9%,respectively. Conclusion:Domestic lovastatin has lipid regulating effects as Mevacor does.

关 键 词：高脂血症 药物疗法 洛伐他汀 血脂代谢 

分 类 号：R589.205[医药卫生—内分泌] R972.6[医药卫生—内科学]