体外循环红细胞钙超负荷与损伤的关系  

Relationship Between Calcium Overload and Erythrocytes Injury During Cardiopulmonary Bypass

作　　者：王涛[1] 张青[1] 闫宪刚 张善通[1] 

机构地区：[1]上海医科大学儿科医院

出　　处：《中国循环杂志》1998年第3期167-169,共3页Chinese Circulation Journal

摘　　要：目的：研究体外循环红细胞钙变化规律及其与红细胞损伤的关系，探索体外循环红细胞损伤机制。方法：测定１９９４年１０月至１９９５年３月上海医科大学儿科医院３０例非紫绀型先天性心脏病患儿围体外循环期红细胞钙、钙泵活性、钠泵活性、滤过指数与血浆游离血红蛋白浓度，观察红细胞形态变化。结果：体外循环中红细胞钙、滤过指数、血浆游离血红蛋白浓度进行性增加，钙泵活性与钠泵活性降低，红细胞发生棘状变形及破坏，上述各项指标变化于转流后２小时最明显。红细胞钙与滤过指数、血浆游离血红蛋白浓度呈直线正相关（ｒ＝０．８３和０．６４，Ｐ＜０．０１）。结论：体外循环中红细胞钙超负荷是红细胞损伤的主要机制之一。Objective:To study the relationship between erythrocyte injury and erythrocyte calcium and explore the mechanism of erythrocyte injury in cardiopulmonary bypass (CPB). Methods:The erythrocytes calcium content(E Ca 2+ ),activities of erythrocyte membrane Ca 2+ ,Mg 2+ ATPase and Na +,K + ATPase,index of filtration(IF),and plasma free hemoglubin(F Hb)were assayed in 30 patients with noncynotic congenital heart disease.The morphology of erythrocytes were observed in phasecontrast microscope. Results:During CPB,E Ca 2+ ,IF and F Hb were progressively increased,a

关 键 词：体外循环 红细胞 钙离子 红细胞损伤 

分 类 号：R654.1[医药卫生—外科学]