TGF-β/smad信号通路的负性调节与糖尿病肾病  

Negative Feedback Regulation of TGF-β/smad Signal Transduction and Diabetic Nephropathy

作　　者：克日阿且[1] 尹洪涛[1] 徐勇[1] 

机构地区：[1]泸州医学院附属医院内分泌科

出　　处：《医学综述》2009年第11期1683-1686,共4页Medical Recapitulate

基　　金：国家自然科学基金(C03030206)

摘　　要：转化生长因子β（TGF-β）家族广泛存在于生物体内,它对于组织器官纤维化起着重要作用。smad蛋白是TGF-β受体的胞内激酶底物,介导了TGF-β的胞内信号转导。TGF-β/smads信号通路与糖尿病肾病关系密切,并且存在多种负反馈调节机制,例如包膜受体水平,胞内smad蛋白及核内转录因子水平的反馈调节。深入了解TGF-β/smad信号通路的负性调节机制对于糖尿病肾病的防治至关重要。本文就TGF-β/smad信号通路的负性调节与糖尿病肾病予以综述。Transforming growth factor β （TGF-β） family, widely existing in the biological body, which plays an important role in organ fibrosis. Smad proteins are the intracellular kinase substrate of TGF-β receptor,which mediate the TGF-β intracellular signal transduction. TGF-β/Smads signal pathway is closely related to diabetic nephropathy, and it has a variety of negative feedback regulation mechanism, such as peplos receptor level, intracellular Smad proteins and nuclear transcription factor level. It is crucial to understand the negative regulatory mechanism of TGF-β/Smad signaling pathway for the prevention and treatment of diabetic nephropathy. This article reviews negative regulation of signaling pathway of TGF-βSmad and diabetic nephropathy.

关 键 词：转化生长因子Β SMAD 糖尿病肾病 负性调节 

分 类 号：R587.2[医药卫生—内分泌]