城市与农村不吸烟女性肺组织中DNA加合物含量  

DNA Adduct Levels in Lung Tissue Among Female Nonsmokers Living in Town and Rural Area

作　　者：吕京[1,2] 杨柯[1,2] 崔涛[1,2] 谢汇江 张海青[1,2] 孟庆海[1,2] 赵志文[1,2] 贺锡雯[1,2] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所 [2]北京市结核病胸部肿瘤研究所

出　　处：《环境与健康杂志》1998年第3期106-107,110,共3页Journal of Environment and Health

基　　金：国家自然科学基金

摘　　要：为更客观地评价空气污染与肺癌的关系，用３２Ｐ后标记法检测城市与农村不吸烟女性肺癌患者与非肺癌患者正常肺组织中ＤＮＡ加合物的含量。城乡妇女、城乡肺癌患者、城乡非肺癌妇女、城市肺癌妇女与农村非肺癌妇女、农村肺癌患者与非肺癌妇女之间均未见统计学差异，但发现城市患者比农村患者，肺癌患者比非肺癌患者的肺组织ＤＮＡ加合物含量高的趋势。To assess the relationship between air pollution and lung cancer more objectively,DNA adduct levels in lung tissues obtained both from female patients with lung cancer and without lung cancer who were nonsmokers living in town and in rural area were detected with 32P postlabeling assayThe results showed that DNA adduct levels presented no differences in all groups,such as:patients in city and rural,patients with lung cancer in city and rural,patients without lang cancer in city and rural,patients in city with lung cancer and in rural without lung cancer,patients in rural with and without lung cancerHigher DNA adduct levels were found in city patients and patients with lung cancer living in towns or in rural areas

关 键 词：肺癌 DNA加合物 非吸烟女性 空气污染 

分 类 号：R122.1[医药卫生—环境卫生学]