O-连接的N-乙酰葡糖胺糖蛋白的研究进展  

Advances in the Study on O-linked N-acetylglucosamine

作　　者：潘丽晶[1,2] 庞义[1] 

机构地区：[1]中山大学有害生物控制与资源利用国家重点实验室,广州510275 [2]珠海市农业科学研究中心,珠海519070

出　　处：《生物技术通报》2009年第6期25-29,共5页Biotechnology Bulletin

基　　金：国家自然科学基金项目(30370965);国家重大基础研究项目(2003CB114202)

摘　　要：O-连接的N-乙酰葡糖胺(O-GlcNAc)修饰是普遍存在的翻译后修饰。已有许多的蛋白被发现是O-GlcNAc蛋白。目前,许多分析方法可以检测O-GlcNAc,将其从内膜系统的多种糖基化中区分出来。O-GlcNAc修饰在细胞事件中发挥着重要的功能,O-GlcNAc的调控异常可能会引起某些人类疾病,如癌症、阿尔茨海默病和II型糖尿病。杆状病毒GP41蛋白也是糖蛋白,它介导芽殖型病毒粒子(budded virus,BV)的核衣壳通过胞核。O-GlcNAc的调控研究为探讨GP41蛋白O-Glc-NAc的调控作用提供了参考模式。O-linked-N-aeetylglucosamine （O-GlcNAc） that has been found on a diverse range of proteins,involed in common post-translational modification. Various analytical methods have been developed to detect O-GlcNAc and distinguish it from glyeosylation in the endomembrane system. It is clear that O-GlcNAc plays a critical function in key cellular events. Dysregulation of O-GleNAc metabolism is correlated with human diseases such as tumorigenesis, Alzheimer＇s disease, diabetes. Research in the control of O-GlcNAc modification could contribute to the research on regulation of O-GlcNAc in GP41, which was required for the egress of nueleoeapsids from the nucleus in the pathway of the budded virus （BV）synthesis.

关 键 词：O-连接的N-乙酰葡糖胺 分析方法 功能 杆状病毒 GP41 

分 类 号：Q51[生物学—生物化学]