乙型肝炎病毒C蛋白和X蛋白的修饰及其意义  

Study on Modifications of HBV Core and X Protein

作　　者：钱冠华[1] 段昌柱[2] 

机构地区：[1]重庆医科大学细胞生物学与遗传学教研室,重庆400016 [2]重庆医科大学分子医学与肿瘤研究中心,重庆400016

出　　处：《生物技术通报》2009年第6期30-33,37,共5页Biotechnology Bulletin

基　　金：国家自然科学基金项目(30872248);重庆市自然科学基金项目(CSTC;2008BB5400)

摘　　要：乙型肝炎病毒(HBV)作为一个外来入侵的病毒可以激发人体的免疫反应,导致人体一系列与HBV感染有关的病理变化与临床表现。HBC和HBX是由HBV基因编码的两种重要蛋白。HBC对病毒基因组的复制和成熟是必不可少的,其蛋白修饰后的产物对病毒在宿主细胞内的组装、成熟和对外分泌中发挥着作用。HBX能与多种蛋白发生相互作用,在HBV的复制中起着不可或缺的作用,也影响着肝细胞癌的形成。现有的对HBC和HBX的磷酸化和泛素化过程的研究,为进一步揭示HBV的致病机制提供了依据,希望最终为乙型肝炎的临床治疗寻找一条新的途径。Hepatitis B virus can stimulate the immune response and result in a series clinical and pathological situations. As a foreign invasion, HBC and HBX are two important proteins in HBV. HBC is essential to replication and maturity of viral genome and the products of modifying HBC play important roles in assemblling, mature and external secretion of HBV in host cells. HBX plays an indispensable role in replication, and also affects the formation of hepatocellular carcinoma. In addition, HBX interacts with a variety of proteins. The researches of phosphorylation and ubiquitination processes of HBC and HBX provided a basis for revealing the pathogenic mechanisms of HBV, and eventually, thus, can help to find a new clinical treatment of virus hepatitis type B.

关 键 词：乙型肝炎病毒核心蛋白 乙型肝炎病毒X蛋白 磷酸化 泛素化 

分 类 号：R373[医药卫生—病原生物学]