维甲酸洗脱支架的制备与体外释放度研究  

Preparation and in Vitro Release Profile of Retinoic Acid-eluting Stents

作　　者：杜玲玲[1] 刘宗军[2] 

机构地区：[1]上海交通大学医学院附属仁济医院药剂科,200001 [2]上海市普陀区中心医院心内科,200062

出　　处：《医药导报》2009年第6期776-778,共3页Herald of Medicine

摘　　要：目的探讨维甲酸洗脱支架的制备方法,考察其体外释放度。方法配制溶质浓度分别为10和7 mg.mL-1的维甲酸层涂层液和聚合物层涂层液,采用气体雾化喷涂法制备维甲酸洗脱支架,在37℃、20%甲醇溶液中进行体外释放实验,通过改变维甲酸层中药物百分比以及聚合物层厚度调节维甲酸洗脱支架释放度。结果喷涂溶质中维甲酸含量为30%的涂层液1 mL,或先喷涂50%维甲酸1 mL后,再喷涂聚合物层涂层液0.5 mL,这两种方法制备得到的维甲酸洗脱支架在可以持续释放约1个月。结论两种方法制备得到的维甲酸洗脱支架在体外具有良好的药物控释行为和机械性能,可以满足动物实验要求。Objective To develop a method for preparing retinoic acid-eluting stents （RAESs） and investigate their release behavior in vitro. Methods The retinoic acid layer and polymer layer were prepared at the content of 10 and 7 mg · mL^-1（W/V） , respectively, and were coated on the bare metal stents by the air-spraying method; The release kinetics of RAES in vitro were carried out in 20% methonol solution at 37℃, the drug percent and layer thickness in retinoic acid layer were adjusted . Results RAESs prepared with only 1 mL 30% retioncid acid layer solution,or with 1 mL 50% retioncid acid layer solution followed by 0.5 mL polymer layer, could consistently release over 30 d. Conclusion RAESs prepared in two ways above have a good control-release and mechanical functions, which is suitable for further animal experiments.

关 键 词：维甲酸 洗脱支架 体外释放度 

分 类 号：R972[医药卫生—药品] TQ460.6[医药卫生—药学]