流动注射-化学发光方法测定盐酸萘甲唑林和盐酸氧甲唑林  

Flow-injection chemiluminescence method for determination of naphazoline hydrochloride and oxymetazoline hydrochloride

作　　者：王楠楠[1] 邵艳清[1] 唐玉海[2] 银和平[1] 

机构地区：[1]内蒙古医学院第二附属医院,呼和浩特010030 [2]西安交通大学理学院分析科学研究所,西安710061

出　　处：《分析试验室》2009年第6期80-83,共4页Chinese Journal of Analysis Laboratory

摘　　要：H2SO4酸性条件下，甲醛对KMnO4-盐酸萘甲唑林（盐酸氧甲唑林）化学发光体系有较强的增敏作用，且强度与药物浓度呈良好的线性关系。据此，建立了采用KMnO4-甲醛体系测定制剂中盐酸萘甲唑林（盐酸氧甲唑林）的流动注射．化学发光分析法。在优化的实验条件下，盐酸萘甲唑林在1．0×10^-8～7．0^10^-6g／mL范围内呈良好的线性关系，检出限为8．69×10^-9g／mL；盐酸氧甲唑林在5．0×10^-8～1．0×10^-5范围内呈线性关系，检出限为3．47×10^-8g／mL。对浓度为1．0×10^-6g／mL的盐酸萘甲唑林和盐酸氧甲唑林分别进行的11次平行测定，RSD分别为4．0％和4．1％。A sensitive and simple flow-injection chemiluminescence （FI-CL） method, which was based on the CL intensity generated from the redoxreaction of potassium permanganate （KMnO4）-formaldehyde in vitriol acid （H2SO4） medium, has been developed, validated and applied to the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. Under the optimum conditions, the linear ranges were 1.0 × 10^-8 -7.0 × 10^-6 g/mL for naphazoline hydrochloride and 5.0 × 10^-8 - 1.0 × 10^-5 g/mL for oxymetazoline hydrochloride. The relative standard deviations （RSD） were 4.0% and 4.1% for 11 replicate measures of 1.0 × 10^-6 g/mL sample solutions. The detection limits were 8.69 × 10^-9 g/mL for naphazoline hydrochloride and 3.47 × 10^-8 g/mL for oxymetazoline hydrochloride （S/N≤3）.

关 键 词：流动注射-化学发光 KMNO4 甲醛 盐酸萘甲唑林 盐酸氧甲唑林 

分 类 号：O657.3[理学—分析化学]