印楝素光氧化物的结构表征及其生物活性  

Structure Confirm and Bioactivity of Azadirachtins Photo-oxide

作　　者：赵淑英[1] 陈艳丽[1] 张振伟[1] 

机构地区：[1]济南大学化学化工学院,济南250022

出　　处：《农药》2009年第6期411-413,418,共4页Agrochemicals

基　　金：山东省中青年科学家奖励基金项目(2005bs0612)

摘　　要：通过光氧化将生物活性较差的nimbin和salannin转化成活性较高的带有印楝素A结构的2种同分异构体,分别为nimbinolide、isonimbinolide和salanninolide、isosalanninolide,产物由液-质联用仪分析定性表征,并对呋喃环转变成环氧丁内酯的氧化机理进行了初步探讨。室内杀虫实验表明氧化产物的生物活性有明显的提高。In order to improve the performance, isomeric products nimbinolide and isonimbinolide containing a hydroxylbutenolide, formed from the furan ring, were produced by the photo-oxidation of the triterpenoid nimbin, an analogous pair of isomers salanninolide and isosalanninolide was similarly formed by oxidation of salannin. The results was indicate by HPLC-MS, The mechanisms of the photo-oxidation were investigated, Azadirachtins bioassay against the third instars larva of Plutella xylostella were investigated, the results indicated that the bioassay of afer photo-oxidation was higher than crude extracts.

关 键 词：印楝素 光氧化 机理 

分 类 号：TQ450.2[化学工程—农药化工]