维生素C泡腾片主组分的吸湿性  

The study of major content in Vitamin C effervescence tablet on moisture absorption

作　　者：李萤[1] 刘永琼[1] 祝宏[1] 李俊杰[1] 李胜松[1] 

机构地区：[1]武汉工程大学化工与制药学院绿色化工过程省部共建教育部重点实验室,湖北武汉430074

出　　处：《武汉工程大学学报》2009年第5期14-17,共4页Journal of Wuhan Institute of Technology

摘　　要：考察了维生素C泡腾片主组分的吸湿变化情况,为其生产制备环境提供理论支持.采用25℃、相对湿度为75%条件下测定各组分的吸湿速率和吸湿质量分数,确定吸湿平衡时间,在33%、43%、75%以及92.7%的湿度下测定平衡后的吸湿质量分数,对吸湿曲线分段拟合研究其吸湿动力学行为,并根据25℃不同湿度条件下的吸湿平衡曲线测定其临界相对湿度.将不同粒径的酒石酸进行吸湿对比实验.结果表明,维生素C、柠檬酸、蔗糖、酒石酸和碳酸氢钠的临界相对湿度分别为96%、74%、85%、83%、90%.根据吸湿平衡经验公式计算得到运用于生产车间的相对湿度53%(含柠檬酸)和61%(含酒石酸).各组分中吸湿快慢依次为柠檬酸、蔗糖、酒石酸、维生素C和碳酸氢钠.不同粒度的酒石酸,颗粒越小吸湿性越强.作为泡腾片原料,酒石酸稳定性要强于柠檬酸.To review the change circumstance of moisture absorption of each content in Vitamin C effervescence tablet and to provide theoretic for its production environment. Measured the moisture absorption rate and moisture absorption percent of each ingredient at 25 ℃, 75% relative humidity conditions, established the moisture absorption equilibrium time, and measured the moisture absorption percent at 33%, 43%, 75% and 92. 7% humidity after equilibrium, studied the moisture absorption kinetics action by its subsection and fitting, and measured their critieal relative humidity according to the moisture absorption equilibrium curve at 25 ℃ ,different humidity. The rsults show the critical relative humidity of Vitamin C, citric acid, sucrose, tartaric acid and sodium bicarbonate are 96%, 74%, 85%, 83%,90%. The relative humidity used for production calculated according to the moisture absorption equilibrium experience formula are 53% （for citric acid） and 61% （for tartaric acid） respectively. For different granularity substance,the smaller the granule is, the stronger the moisture absorption is; the moisture absorption rate from fastest to slowest are citric acid, sucrose, tartaric acid, Vitamin C and sodium bicarbonate in turn. The stability of effervescence tablet used tartaric acid as raw material is stronger than using citric acid.

关 键 词：维生素C 泡腾片 主组分 吸湿性 临界相对湿度 

分 类 号：R944.4[医药卫生—药剂学]