甲状腺激素对小鼠细胞免疫及体液免疫的影响  

EFFECTS OF THYROXINE ON THE IMMUNITY IN MICE

作　　者：董建英[1,2] 周南南[1,2] 

机构地区：[1]江西医学院生理学教研室 [2]江西医科大学微生物学教研室

出　　处：《中国免疫学杂志》1998年第3期184-186,共3页Chinese Journal of Immunology

基　　金：江西省自然科学基金

摘　　要：用注射Ｌ－Ｔ４和ＰＴＵ灌胃的方法成功地制备了甲状腺机能增高（甲高）和甲状腺机能减低（甲低）小鼠模型，并对这些小鼠的免疫功能进行了检测。发现甲低小鼠脾细胞数减少，甲高和甲低小鼠脾细胞对ＣｏｎＡ反应性减弱。甲高小鼠ＩｇＭ产生增加，而甲低小鼠ＩｇＭ产生降低。但此两组甲状腺机能异常小鼠的ＩｇＧ产生均受到抑制。此外，还发现甲低小鼠脾脏中Ｔｓ细胞比值增加。n order to investigate the in vivo effect of thyroxine on immunity, the authors prepared hyperthroid mice by subcutaneous injection of Ltetraiodothyronine(LT4) and hypothyroid mice by oral administration of propylthiouracil(PTU). In mice rendered hypothyroid splenic cells were decreased. The reactivities of splenic lymphocytes to concanavalin A were depressed in both hyperthroid and hypothroid mice. The primary immune response in hyperthyroid mice to an injection of SRBC showed an increase in IgM plaque forming cells(IgMPFC). However, in hypothyroid mice the IgMPFCs were decreased. At the tenth day after challenged by SRBC, both hyper and hypothyroid mice produced less IgGPFCs in spleens than did normal mice. In addition, an increased percentage of suppressor T lymphocytes was found in spleens of hypothyroid mice, which may contribute to inhibition of immunity in the mice.

关 键 词：甲状腺激素 甲状腺疾病 细胞免疫 体液免疫 

分 类 号：R392.1[医药卫生—免疫学] R581[医药卫生—基础医学]