可编程式经皮神经肌肉电刺激系统的设计及初步实验研究  

Design of Programmable Transcutaneous Neuromuscular Electrical Stimulation System and Its Primary Experimental Study

作　　者：牛川森[1] 胡春华[2] 郝红伟[2] 李路明[2] 吴敏生[1] 

机构地区：[1]清华大学机械工程系,北京100084 [2]清华大学宇航技术研究中心,北京100084

出　　处：《航天医学与医学工程》2009年第3期211-215,共5页Space Medicine & Medical Engineering

基　　金：国家863计划资助(2006AA02Z4E9);国家科技支撑计划资助(2006BAI03A18)

摘　　要：目的研究可用于中长期失重环境下肌肉萎缩对抗的可编程式经皮神经肌肉电刺激系统的设计及其应用。方法由可控恒流脉冲发生器、导线、皮肤电极组成系统,针对刺激处方筛选的要求,刺激脉冲参数独立可调且能实现不同刺激阶段的组合输出。结果系统样机工作正常,输出信号精确;不同波形的脉冲电流都能引起股四头肌的感觉、收缩、强直及疼痛,但所需幅度阈值不同,相同幅度刺激引起的主观感受也存在差异。结论研制的系统输出信号准确、可编程功能强大,便于进行刺激处方的筛选和验证,可作为失重环境下肌肉萎缩的电刺激对抗研究的仪器平台;人体试用实验验证了刺激系统的功能性,为刺激参数的优化提供了初步依据。Objective To develop a programmable neuromuscular electrical stimulation system as a potential countermeasure for muscle atrophy in long-term microgravity. Methods The system was mainly composed of a controllable constant current pulse generator, wires and skin electrodes. To meet the requirements of stimulating recipes selection, the stimulating parameters could be adjusted independently and the combinatorial output of different stimulating phases should also be achieved. Results The system worked well with high accuracy outputs. The sensation, contraction, tetany and pain thresholds of all the 5 waveforms stimulating signals were measured. For different stimulating waveforms, thresholds of each state were different and the subjective sensations induced by same stimulating amplitude were dissimilar. Conclusion The developed system providing powerful programmable and accurate stimulating signals, is convenient for the selection and verification of stimulating recipes and can be used as an instrument platform for study of electrical stimulation to prevent muscle atrophy in microgravity. Volunteer experiments have proved its validation for function of muscle contraction and provide primary basses for the optimization of stimulating recipes.

关 键 词：微重力 肌肉萎缩 经皮 神经肌肉电刺激 

分 类 号：R312[医药卫生—基础医学]