微重力条件下免疫系统相关黏附分子的研究进展  

Advanced Researches on Cell Adhesion Molecules of Immune System under Microgravity

作　　者：张宇[1] 桑晨[1] 庄逢源[1] 

机构地区：[1]北京航空航天大学生物与医学工程学院,北京100191

出　　处：《航天医学与医学工程》2009年第3期231-234,共4页Space Medicine & Medical Engineering

基　　金：国家自然科学基金项目资助(10672013)

摘　　要：微重力环境可导致航天员免疫机能下降和易于感染。而在免疫系统中黏附分子对于免疫功能的正常行使起重要的调控作用,因此,研究微重力条件下细胞黏附分子的变化不仅可以了解微重力对免疫功能影响的分子机制,也有助于研究细胞对于重力感知的相关机制。本文主要介绍微重力条件下,免疫系统相关的细胞粘附分子所介导的信号通路、基因表达调控以及对细胞功能影响等的最新研究进展。Returning astronauts had experienced decreased immune function and increased vulnerability to infection during spaceflights. In immune system, cell adhesion molecules （CAMs） play an important role in regulating immune response in normal physiological conditions. Studying changes of CAMs under microgravity could not only understand the effects of microgravity and its molecular mechanism on immune function, but also help to study the relative mechanism about cell sensation of microgravity. In this review, we will introduce some downstream signal pathways, gene expression and the effects on cell functions under microgravity. All of them are regulated by cell adhesion molecules related with the immune system.

关 键 词：微重力 免疫系统 细胞粘附分子 信号转导 

分 类 号：R854[医药卫生—航空、航天与航海医学]