焦炉作业多环芳烃暴露工人诱发电位检测  

Determination of evoked potential in coke oven workers

作　　者：聂继盛[1] 张红梅[1] 孙建娅[2] 石樱桃[3] 张玲[1] 牛侨[1] 

机构地区：[1]山西医科大学公共卫生学院劳动卫生教研室,太原030001 [2]太原钢铁集团有限公司疾病预防控制中心 [3]山西省肿瘤医院

出　　处：《中国公共卫生》2009年第6期738-739,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金(30471437);山西省自然科学基金(20051093)

摘　　要：目的检测多环芳烃暴露人群诱发电位的变化情况。方法按炉顶、炉侧、炉底不同作业岗位各随机选取15名焦炉工为暴露组,另选一般情况相近的25名库工为对照组。高效液相色谱法检测研究对象尿中1-羟基芘水平;Neuropack M1肌电图仪进行体感诱发电位(SEP)、听觉诱发电位(AEP)和视觉诱发电位(VEP)的测定。结果尿中1-羟基芘对照组、炉底组、炉侧组、炉顶组分别为(2.71±0.22),(3.29±0.38),(3.63±0.55),(4.13±0.62)μmol/mol Cr,呈现炉顶>炉侧>炉底>对照的趋势;各组体感诱发电位、听觉诱发电位和视觉诱发电位各指标经方差分析,差异无统计学意义(P<0.05)。结论在目前的接触水平下,多环芳烃暴露人群躯体感觉传导通路、听觉传导通路和视觉传导通路未发生明显异常。Objective To explore the effect of polycyclic aromatic hydrocarbons on the evoked potential in coke oven workers. Methods Forty-five healthy male coke oven workers were selected randomly from a coke plant of a state-owned steel enterprise in Taiyuan city according to their work sites. Twenty-five controls of unexposed to polycyclic aromatic hy- drocarbons （PAHs） occupationally were selected from the same enterprise. Urine samples were collected immediately after working shift. The level of urinary 1-hydroxypyrene was determined by High Performance Liquid Chromatography （HPLC）. General information of workers correlated with the investigation was collected with questionnaire by trained inter- viewers. The sensory, auditory and pattern-visual evoked potentials were monitored by neuqopack M1 （Nihon Kohden corpo- ration）. Results No significant difference was found among four groups of different age,length of service, smoking, drink- ing,educational level and unhealthy food consumption. Urinary 1-hydroxypyrene were significant diffenert among four groups, with a tendency of oven top 〉 oven side 〉 oven bottom 〉 control. Compared with the controls, there was no signifi- cant difference in the sensory evoked potencial, auditory evoked potencial and pattern-visual evoked potencial among four groups. Conclusion The results suggest that PAHs have no effect on the sensory veoked potencial,auditory evoked potencial and pattern-visual evoked potencial in coke oven workers.

关 键 词：焦炉作业 多环基烃 诱发电位 

分 类 号：R135.13[医药卫生—劳动卫生]