氨苄西林磁性明胶药物微球的制备及控制释放  

The Preparation and Controlled Release of Magnetic Gelatin Drug Microsphere of Ampicillin

作　　者：商丹[1] 张朝平[1] 申德君[2] 

机构地区：[1]贵州大学理学院化学系,贵州贵阳550025 [2]贵阳学院化学与材料学系,贵州贵阳550008

出　　处：《高校化学工程学报》2009年第3期537-542,共6页Journal of Chemical Engineering of Chinese Universities

基　　金：贵州省教育厅科技基金[2002(101)];贵州省省长基金[2003(05)]资助项目

摘　　要：将药物封装入一个输送系统,以便在适当时间内持续控制药物释放。为此,利用明胶的生物相容性,选用难溶性氨苄西林(AMP)为药物模型,Fe3O4作为磁性内核,戊二醛作交联固化剂,液体石蜡为有机分散介质,采用反相悬液冷冻凝聚法(RPSCC)制备出了磁性AMP明胶核壳微球。用SEM、FT-IR和UV/Vis光谱等考察了药物微球的结构和外观形貌,以及药物在包封后的性质。结果表明磁性明胶药物微球的粒径小于20μm。氨苄西林微球载药率(w/w)为7.1%,Fe3O4的含量为22.1%,微球包裹率为65.13%。7h内释放的药物占总含药量的72.3%。微球的缓释性能良好。In order to control a predetermined quantity of drug release in a proper period continually, drugs were encapsulated in a specific delivery system. For this purpose, the biological compatible gelatin was used for the preparation of the microcapsule, and the indissoluble Ampicillin （AMP） was used as the model drug. At the preparation, the Fe304, the glutaric dialdehyde and the liquid paraffin were used as magnetic-core, cross-linking agent and dispersing medium, respectively. The magnetic AMP drug gelatin microcapsule were prepared by means of the reverse phase suspension cold-condensation （RPSCC） method, and the microcapsule prepared were characterized by scanning electron microscopy （SEM）, Fourier transform infrared spectroscopy （FT-IR）, ultraviolet/visible absorptive spectrum （UV/Vis）, etc.. The results show that the prepared microcapsules have spherical shape with smooth surface, and the diameters of the prepared microspheres are below 20 μm. In the microcapsules, the contents of Ampicillin and Fe304 are 7.1%（W/W） and 22.1%, respectively, and the drug encapsulation efficiency is 65.13%（W/W）; the amount of drugs released from the mieroeapsule in 7 h is 72.3% of its total drug content. It shows that the magnetic gelatin drug microsphere prepared has good drugs sustained releasing property.

关 键 词：明胶 氨苄西林 磁性微球 制备 控制释放 

分 类 号：TM277[一般工业技术—材料科学与工程] R944.9[电气工程—电工理论与新技术]