孕妇血清PLGF含量与子痫前期的风险  

Serum PLGF and risk of preeclampsia

作　　者：王江玲[1] 许张晔[1] 周洁[1] 张文辉[1] 孟媛[1] 黄引平[1] 

机构地区：[1]温州医学院附属第一医院,浙江温州325000

出　　处：《中国卫生检验杂志》2009年第5期1062-1063,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的：探讨孕妇血清胎盘生长因子（PLGF）含量与子痫前期风险的相关性。方法：2005/3-2006/11收集本院200例孕妇资料,自孕10周-14周始,直至临产,在不同时间段抽取各组孕妇的外周血,ELISA测定PLGF含量。统计学分析不同孕周以及不同程度子痫前期发生前后的PLGF含量变化。结果：检测时未发生子痫前期,而在以后时间段发病的病例,在30周时达到PLGF含量峰值,但水平明显低于正常对照（P〈0.05）。在子痫前期发生之前5周,血清PLGF含量即有显著下降（P〈0.01）。结论：子痫前期的病理过程中,PLGF表达异常,并且其含量的改变先于临床症状的出现,可作为临床参考的依据。Objective：To determine the relationship between serum placenta growth factor （PLGF） and the risk of preeclampsia. Methods：During 2005/3 - 2006/11, clinical records of 200 pregnant women were collected and reviewed. From 10 -14 weeks of gestation till delivery, their peripheral blood specimens were obtained at intervals. The PLGF levels were measured with ELISA and the results were analyzed from individuals with variant severity of preeclampsia at variant time points. Results ： Women who were undetcctable at measurement but later had preeclampsia also reached the peak at the same time. However, the levels were significantly lower than the controls （ P 〈 0. 05 ）. Five weeks before the onset of preeclampsia, there was already significant evidence of decreases in serum PLGF （P 〈 0.01 ）. Conclusion： During the pathological process of preeclampsia, abnormal expression of PLGF is present prior to clinical symptoms, which can be taken as a biomarker for prevention and early diagnosis.

关 键 词：子痫前期 胎盘生长因子 血清 

分 类 号：R714.245[医药卫生—妇产科学]