代谢综合征患者干预治疗后血清抵抗素的动态变化及其影响因素的研究  

Observation of dynamics of serum resistin level and its influencing factors in patients with metabolic syndrome after interventional therapy

作　　者：胡天勇[1] 刘鹏[1] 关怀敏[1] 解金红[1] 王枫岭[1] 李靖[1] 赵杰娉[1] 张燕[1] 陈玉善[1] 张辉[1] 李刚[1] 李莉[1] 罗明华[1] 

机构地区：[1]河南省胸科医院心内科,郑州450003

出　　处：《中国卫生检验杂志》2009年第5期1064-1065,1073,共3页Chinese Journal of Health Laboratory Technology

基　　金：河南省卫生厅创新人才工程(200595)

摘　　要：目的：探讨干预治疗对代谢综合征（Metabolic Syndrome,MS）患者血清抵抗素水平的影响,并分析影响血清抵抗素的因素。方法：入选2006年3月-2008年1月于我院门诊或住院的MS初诊患者48例,连续检测患者入选时基线水平、治疗后4周、24周及48周的血清抵抗素水平,根据预测未来10年冠心病发生概率的Framingham危险评分将患者分为3组：低危组（〈10%）,中危组（10-20%）,高危组（〉20%）。干预治疗措施包括：治疗性生活方式转变（减重、增加体力活动、饮食调节等）,药物治疗（降压、降糖、调脂等）。比较三组间同一时间点及同组内不同时间点血清抵抗素水平的差异。多元线性回归分析影响血清抵抗素的因素。结果：MS的血清抵抗素水平于基线、治疗后4周、24周及48周时分别为72±38μg/L,56±29μg/L,40±21μg/L,30±11μg/L（F=23.836,P〈0.001）;3组间不同时间点血清抵抗素水平均有差异（P〈0.001）,各组内不同时间点的比较均有差异（P〈0.01）。Spearman秩相关分析显示Framingham危险评分和血清抵抗素水平的相关性系数rs=0.792（P〈0.001）,控制C-RP后,偏相关分析显示两者间仍呈正相关（rs=0.766,P〈0.001）;多元线性回归分析显示Framingham危险评分和C-RP是影响血清抵抗素水平的主要因素（前者β=0.589,t=7.216,P〈0.001;后者β=0.483,t=6.123,P〈0.001）。结论：规范化的干预治疗可明显降低代谢综合征患者的血清抵抗素水平,而Framingham危险评分和C-RP是影响血清抵抗素水平的主要因素。Objective：To observe the dynamics of serum resistin level and its influencing factors after intervention therapy in patients with metabolic syndrome （MS）. Methods ：48 subjects were divided into three groups： low risk group （ 〈 10% ）, intermediated group （10% - 20% ） and high risk group（ 〉 20% ）, according to Framingham scores. The resistin levels in all patients at baseline, 4, 24 and 48 w after intervention was respectively examined. And the influencing factors of serum resistin level was analyzed by multiple regression analysis. Results： The serum resistin level was significantly lower at 4, 24 and 48 w after intervention （72 ±38 μg/L, 56 ±29 μg/L, 40 ±21 μg/L, 30 ± 11 μg/L, F =23. 836, P 〈0. 001 ） ; Partial correlation analysis showed that there was just positive relationship between the serum resistin level and Framingham scores in the patients with MS（ rs = 0. 766, P 〈 0. 001 ） after adjusting C - RP factor. The regression analysis showed that the importantly influencing factors of serum resistin were Framingham scores and C - RP（ the formerβ = 0. 589, t = 7. 216, P 〈 0. 001 ; the latterβ = 0. 483, t = 6. 123, P 〈 0. 001 ）. Conclusion：Standardized intervention could significantly deereas the resistin level in the MS patients, and the Framingham scores and C - RP are important influencing factors of serum resistin.

关 键 词：抵抗素 代谢综合征 干预治疗 影响因素 

分 类 号：R446.1[医药卫生—诊断学]