脂蛋白脂酶基因Hind Ⅲ多态性与冠心病相关性的meta分析  

Meta-analysis on correlation between polymorphism of Hind Ⅲ in LPL gene and coronary heart disease

作　　者：翟光华[1] 李美芬[1] 

机构地区：[1]苏州市立医院北区检验科

出　　处：《中国循证心血管医学杂志》2009年第3期144-147,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的对中国汉族人脂蛋白脂酶（LPL）基因HindⅢ多态性H＋H＋基因型与中国人群冠心病的相关性进行meta分析。方法制定文献的纳入标准，检索中国期刊全文数据库、万方数据库、维普信息数据库、PubMed及中国学术期刊博硕士学位论文全文数据库等关于LPL基因HindⅢ多态性与冠心病相关性的原始研究，评价纳入文献质量，进行meta分析。结果7项研究被纳入meta分析，其中冠心病患者1184例，对照组1004例。按Peto固定效应模型合并后，LPL基因的HindⅢ多态性H＋H＋基因型／（H＋H-／H-H＋）基因型的OR值为1．22，95％CI为1．02—1．46，P=0．03。结论LPL基因HindⅢ多态性可能与中国汉族人群冠心病发病有关。Objective To carry out Meta-analysis on the correlation between polymorphism of Hind III in lipoprotein lipase（LPL） gene （ H＋ H＋ genotype） and coronary heart disease（CHD） in Chinese Han people. Methods The inclusion criteria of literatures was drawn up, and then the original study literatures on the correlation between polymorphism of Hind Ⅲ in LPL gene and CHD were retrieved from Chinese Journal Full-Text Database （CJFD）, WanFang Database, PubMed and Chinese Academic Journal and Doctoral Dissertation and Master＇s Thesis Full-Text Database. The quality of the literatures was reviewed and analyzedby Meta-analysis. Results There were 7 studies included into Meta - analysis, in which there were 1 184 cases in CHD group and 1 004 in the control group. After combination according to Peto-fixed effect model OR value of polymorphism of Hind 111 in LPL gene [H＋ H＋ genotype/（H＋ H-/H-H- genotype）] was 1.22 （95 % CI： 1.02 - 1.46, P = 0.03）. Conclusion The polymorphism of Hind Ⅲ in LPL gene may be related to the onset of CHD in Chinese Han people.

关 键 词：脂蛋白脂酶 基因 多肽现象 限制性片段长度 冠状动脉病变 系统评价 

分 类 号：R541.4[医药卫生—心血管疾病]