热痹颗粒对AA大鼠Bcl-2蛋白表达及IL-1β、TNF-α的影响  

Influence of Rebi Granule on Expressions of Bcl-2,IL-1β and TNF-α in AA Rats

作　　者：王勇[1] 章敏[2] 李羚青[2] 胡爱萍[2] 赵映前[3] 

机构地区：[1]武汉体育学院,武汉430079 [2]湖北中医学院 [3]湖北省中医院

出　　处：《中国中医骨伤科杂志》2009年第6期8-9,共2页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省科技厅科技攻关项目;编号:2003AA02B02

摘　　要：目的:研究热痹颗粒治疗类风湿性关节炎的作用机理。方法:以佐剂性关节炎大鼠(AA)作为实验模型,热痹颗粒为阳性对照药物,随机分为6组(正常组、模型组、对照组、热痹颗粒小剂量组、中剂量组和大剂量组)进行实验研究,观察热痹颗粒对AA大鼠Bcl-2蛋白表达及IL-1β、TNF-α的影响,对其作用机理进行探讨。结果:热痹颗粒能够下调Bcl-2蛋白的表达,降低血清中IL-1β、TNF-α的水平。软骨的破坏,使关节损伤减轻。结论:该药具有较好的抗炎和免疫调节作用,能改善细胞因子紊乱,减轻关节炎性细胞浸润及滑膜炎性增生。Objective：To study the mechanisms of Rebi Granule （RG） in treating rheumatoid arthritis （RA）. Methods：Adjuvant-induced arthritis （AA） rat models were established and Wangbi Granule （WG） was used as positive control. Rats were divided randomly into normal group, model group, control group, RG low-dosage group, middle-dosage group and high-dosage group. Bcl-2, IL-1β and TNF-αexpressions were observed. Results： RG downregulated the expression of Bcl-2 and decreased the serum levels of IL-1β and TNF-α in AA rats. Meanwhile, cartilaginous erosion and joint injury were alleviated. Conclusion：RG can modulate disorder of cytokine with antiinflammatory and immunological regulation effects. It also can relieve inflammatory cells infiltrate and synovitis.

关 键 词：热痹颗粒 类风湿性关节炎 BCL-2 IL-1Β TNF-Α 

分 类 号：R684.3[医药卫生—骨科学]