舍曲林与阿米替林治疗81例创伤后应激障碍的疗效比较  

Comparison between Sertraline and Amitriptyline in the treatment of posttraumatic stress disorder

作　　者：劳永志[1] 赵素华[1] 叶莉英[1] 

机构地区：[1]广州市脑科医院,广东广州510370

出　　处：《中国民康医学》2009年第11期1216-1217,1220,共3页Medical Journal of Chinese People’s Health

摘　　要：目的：比较舍曲林与阿米替林治疗创伤后应激障碍的疗效和不良反应。方法：81例创伤后应激障碍患者随机分成两组，分别用舍曲林与阿米替林治疗12周。用症状自评量表（SCL-90）中的躯体化、抑郁和焦虑3个因子总分评定症状变化，用不同减分率评定疗效。用不良反应量表（TESS）评定药物不良反应。结果：舍曲林组痊愈率为61．90％，总有效率为90．48％；阿米替林的痊愈率为43．59％，总有效率为71．79％，两组疗效比较差异有统计学意义（P〈0．05）。两组TESS测评，各时点组间比较，差异有统计学或高度统计学意义（P〈0．05或P〈0．01）。结论：舍曲林治疗创伤后应激障碍疗效确切，不良反应较小。Objective：To compare the therapeutic effects and adverse drug reactions between Sertraline and Amitriptyline in the treatment of somatization disorder. Methods： Eighty - one patients with posttraumatic stress disorder were randomized into 2 groups ,which were treated with Sertraline or Amitriptyline for 12 week. The symptomatic changes were evaluated using the total score of somatization ,depression, and anxiety as described in symptom check - list 90 （ SCL -90 ）, the therapeutic effect was assessed using various subtraction rates. And drug - related adverse drug reactions were evaluated using the treatment emergent symptom scale （TESS）. Results ： The recovery rate was 61.90% in the Sertraline treatment group and 43.59% in the Amitriptyline treatment group, and the total effective rate was 90.48% and 71.79% respectively. The difference in the efficacy between 2 groups was significant （P 〈 0.05 ）. TESS tests revealed that there were significant differences between 2 groups at various time points. Conclusions： Sertraline is effective in the treatment of posttranmatic stress disorder,but has few adverse drug reactions.

关 键 词：创伤后应激障碍 舍曲林 阿米替林 

分 类 号：B845.67[哲学宗教—心理学]