红参预防家兔高血压性视网膜动脉硬化的免疫组化研究  

Immunohistochemical Study on the Effects on Red Ginseng in Preventing Hypertensive Arteriosclerosis of Retina in Rabbits

作　　者：金明[1] 魏育林[1] 赵家良[2] 沈德础[1] 金恩源[1] 潘琳[1] 常春燕[1] 熊谷朗 

机构地区：[1]中日友好医院,北京100029 [2]北京协和医院,北京100005 [3]日本人参研究会

出　　处：《北京中医药大学学报》1998年第3期26-28,共3页Journal of Beijing University of Traditional Chinese Medicine

摘　　要：观察了红参预防高血压性眼底动脉硬化的作用。方法 :采用红参影响相关血管活性物质在眼底血管的免疫组化表达。①制作家兔肾性高血压眼底模型 ;②利用免疫组化的方法观察内皮素 (ET1)、血管紧张素Ⅱ(ANGⅡ)、细胞生长因子 (EGF)在眼底血管的含量变化 ;③利用图象分析仪对各种免疫组化结果进行定量分析 ;结果 :高血压模型组ET1、ANGⅡ、EGF呈深褐色阳性反应 ,含量变化高于用药组。红参能够调节ET1、ANGⅡ、EGF的分泌和表达 ,对高血压性眼底动脉硬化有预防作用。Objective: to observe the effects of red ginseng in preventing hypertensive fundus arteriosclerosis. Method: to qualitatively and quantitatively determine endothelin Ⅰ (ET 1), angiotensin Ⅱ (ANG Ⅱ) and epidrmal growth factor (EGF) in the walls of fundus blood vessels in rabbit renal hypertensive fundus model by immunohistochemical method and by using image analyzer. Result: ET 1, ANG Ⅱ, EGF in the model group showed dark brown positive reaction and their contents were higher than those in the red ginseng treatment group. Conclusion: red ginseng could regulate the secretion and expression of ET 1, ANG Ⅱ and EGF and prevent hypertensive fundus arteriosclerosis.

关 键 词：视网膜动脉硬化 高血压 红参 预防 中药 

分 类 号：R285.5[医药卫生—中药学] R276.741[医药卫生—中医学]