血清抗内皮细胞抗体定量分析与复发性自然流产相关性研究  

Relationship between Antiendothelial cell antibodies and CRP with Repeated spontaneous abortion.

作　　者：杜欣莹[1] 管立学[1] 王美[1] 王丽[1] 郎彦[1] 

机构地区：[1]潍坊人民医院产二科,山东261041

出　　处：《中国优生与遗传杂志》2009年第6期23-25,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察抗内皮细胞抗体(Antiendothelial cell antibodies,AECA)是否为中国人不明原因重复性自然流产(unexplained recurrent spontaneous abortion,RSA)的危险因素,并分析AECA水平与胚胎停育及曾有自然流产不良妊娠史者间的相互关系,并探讨AECA与CRP二者间的关系。方法选择早期妊娠93例,其中病例组(重复性自然流产胚胎发育停止者)37例,正常早期妊娠对照组56例。用ELISA法测血清AECA水平,散射比浊法测CRP定量。结果AECA水平是RSA发病的危险因素,病例组AECA水平明显高于对照组,独立样本T检验t=-4.581,P=0.000(OR值1.079,95%CI:1.012-1.151),差异有显著性意义;发生自然流产的风险是正常人群的1.079倍。通过绘制ROC曲线确定AECA阳性标准为≥60.5 pmol/L,预测自然流产的灵敏度是96.6%,特异度70.6%。CRP含量与AECA定量、妊娠结局及临床症状无相关关系,P>0.05。结论AECA水平与RSA发病密切相关,可较好预测自然流产的发病;以AECA≥60.5 pmol/L作为RSA诊断指标,具有较高的灵敏度和特异度,有望成为一项新的临床诊断参考指标。CRP与AECA及RSA发病无关,血管炎性反应可能不是AECA引起RSA的主要机制。Objective The current study was undertaken to find out the interactions between antiendothelial cell antibodies in women with unexplained recurrent spontaneous abortion （ RSA ）. Methods： This study in 93 early pregnancy women included two groups ： 37 patiens were miscarriages （ RSA group） and 56 control subjects with normal pregnancies. The AECA and CRP level were detected in all cases. Results： AECA level was significantly higher than that in control subjects, t = -4. 581, P =0. 000 （95%CI： 1. 012 - 1. 151 ）. The level of CRP was negatively in two groups, and it was not associated with the AECA too, P 〉 0. 05. The cut - off value of positive AECA was determined as≥60. 5 pmol/L with ROC curve. The sensitivity and specificity was 96. 6%, 70. 6%. Conclusion： The elevated level of AECA is associated with the RSA. AECA ≥60. 5 pmol/L is a sensitive and specific indicator for diagnosing RSA.

关 键 词：重复性自然流产 血清AECA水平 

分 类 号：R714.21[医药卫生—妇产科学]