小于胎龄儿脐血超敏C反应蛋白水平及意义探讨  

High-sensitivity C-reactive protein level in Cord Blood and its clinical significance in small-for-gestational-age neonates.

作　　者：段纯[1] 朱岩[1] 胡运月[1] 龙峰[1] 

机构地区：[1]南方医科大学附属深圳市妇幼保健院检验科,深圳518028

出　　处：《中国优生与遗传杂志》2009年第6期74-74,76,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的比较小于胎龄儿(small-for-gestational-age,SGA)与适于胎龄儿(appropriate-for-gestational age,AGA)脐血超敏C反应蛋白(hs-CRP)水平,探索C反应蛋白与心血管病之间的关系。方法检测32例SGA和66例AGA脐血hs-CRP浓度,排除可疑或经证实的宫内感染。结果SGA组hs-CRP浓度显著高于AGA组,中位数(范围)分别为:SGA组0.06 mg/dl(0.02～6.03)、AGA组0.02 mg/dl(0.02～0.61),P=0.003。hs-CRP浓度高于检测限(0.04mg/dl)分别为:SGA组22例(68.8%)、AGA组26例(39.4%),(P=0.002)。结论SGA组hs-CRP浓度高于AGA组,提示SGA在胎儿期可能有炎症反应。Objective ： To explore the relation of C - reactive protein and Cardiovascular disease by comparing the high - sensitivity C - reactive protein （ hs - CRP） levels in Cord Blood between small - for - gestational - age （ SGA ） and appropriate - for - gestational age （AGA） neonates. Methods ： Levels of hs - CRP were measured in 32 SGA infantsand in 66 AGA neonates. Neonates with a history of suspected or proven fetal - maternal infection were excluded. Results ： In SGA infants, hs - CRP levels were significantly higher than in AGA neonates ： median （range） ; 0. 06 mg/dl （0. 02 - 6.03 ） vs. 0. 02 mg/dl （0. 02 - 0. 61 ） ; P = 0. 003. Levels of hs - CRP were higher than the detection limit （0. 04 mg/dl） in 22 （68. 8% ） SGA infants and in 26 （39.4%） AGA neonates （ P = 0. 002）. Conclusion ： In SGA infants, hs - CRP levels are higher than in AGA neonates suggesting the presence of an inflammatory process in this group of patients during the fetal life.

关 键 词：小于胎龄儿 适于胎龄儿 超敏C反应蛋白 心血管疾病 

分 类 号：R722.1[医药卫生—儿科]