心脑血栓前期联合指标诊断的研究  

Diagnositic significance of union indices in cardio-cerebrovascular prethrombosis

作　　者：黄培山[1] 黄於球[1] 李佑琳[1] 谭志元[1] 佘军红[1] 韦继明[1] 张九莲[1] 

机构地区：[1]广西柳州市工人医院

出　　处：《广西医学》1998年第3期331-335,共5页Guangxi Medical Journal

基　　金：广西区科委和柳州市科委攻关课题

摘　　要：为提高心脑血栓前期诊断的准确性，对１２０例缺血性心脑血管性疾病综合１７项指标检测进行分组分析。结果：１４项指标在各病例组与对照组比较有非常显著性差异（Ｐ＜０．０１），跟踪观察发现１４例不稳定型心绞痛（ＵＡ）、脑动脉硬化（ＣＡＳ）和短暂性脑缺血（ＴＩＡ）患者在２～９个月内发生急性心肌梗塞（ＡＭＩ）或脑梗塞（ＣＩ），其中１１例在梗塞前与ＣＩ和ＡＭＩ病例组的平均异常指标相同。表明综合１４项指标检测对心脑血栓前期诊断的准确性达７９％（１１／１４例），同时筛选出以ＧＭＰ－１４０、ＡＴ－Ⅲ、ＶＷＦ：Ａｇ、６－Ｋ－ＰＧＦ１α、ＴＸＢ２、ｔ－ＰＡ、ＰＡＩ、Ｄ－ｄｍ和Ｆｎ的分子标志物以及血栓弹力图测定均有较高的特异性和敏感性。因此，对心脑血栓前期的诊断，应结合血栓形成的多因素进行综合指标观察，才有可能作出准确度高的预测。To improve the diagnostic accuracy of cardiao-cerebrovascular prethrombosis,120 cases of ischemia cardiac-cerebrovascular disease were analyzed in group by assaying 17 indices Results:there were significant difference between patients group and normal control group in 14 indices (P<001)14 cases of unstable angina(UA),cerebri arteriae sclerosis (CAS)and transient ischemia (TIA)suffered from acute myocardial infarction(AMI)or cerebral infarction(CI) within the following 2 to 9 months,among which 11 cases,before infarction,had the same average unusual indices as AMI and CIThe accuarcy to diagnose cardio cerebrovascular prethrombosis by comprehensively analyzing 14 indices was 79%, also GMP-140、AT-Ⅲ、VWF:Ag,6K-PGF 1a 、TXB 2、t-PA、PAI,D-dm and Fn molecule marker and TEG had much more sensitivity and specificity

关 键 词：血栓前期 缺血性 心脑血管疾病 分子标志物 诊断 

分 类 号：R540.4[医药卫生—心血管疾病] R743.04[医药卫生—内科学]