用HB-H-6树脂血浆灌流治疗重度黄疸临床研究  

Clinical study on plasma perfusion using HB-H-6 resin for the treatment of severe jaundice

作　　者：李涛[1] 杜智[1] 袁萍[1] 韩涛[1] 李隽[1] 方淑昌[1] 骆力群[1] 

机构地区：[1]天津市第三中心医院天津市肝胆疾病研究所卫生部人工细胞工程技术研究中心,天津300170

出　　处：《中国血液净化》2009年第5期264-266,共3页Chinese Journal of Blood Purification

摘　　要：目的观察HB-H-6树脂血浆灌流对重度黄疸的治疗效果。方法选择重度黄疸患者61例,均为急慢性肝衰竭、重型肝炎造成的肝细胞性黄疸。采用一次性使用的HB-H-6树脂吸附胆红素血浆灌流器进行治疗。分别于灌流前和灌流2h取血测定血浆胆红素、蛋白质、电解质和血常规,并观察患者血压、心率、呼吸和体温变化。结果灌流至2h结束,患者血浆总胆红素下降29%,直接胆红素下降26%,间接胆红素下降31%(P<0.05);总蛋白下降6%,白蛋白下降11%,球蛋白下降3%(P<0.05);灌流对血浆电解质钾、钠、氯、钙、镁和磷均无明显影响(P>0.05)。灌流前后相比,白细胞升高2%,红细胞下降1%,血小板下降9%(P>0.05)。灌流过程中,患者血压、心率、呼吸和体温等均无明显变化。结论HB-H-6树脂血浆灌流治疗重度黄疸是一种安全、有效的方法。Objective To observe the effect of HB-H-6 resin plasma perfusion in the treatment of severe jaundice. Methods Sixty-one patients （male 52 and female 9; 44-71 years of age with mean age of 55 years） with severe jaundice were enrolled in this study. They were diagnosed with hepatocellular jaundice caused by acute or chronic liver function failure or severe hepatitis. Patients were treated with HB-H-6 resin plasma perfusion unit. Plasma bilirubin, protein, electrolyte and blood routine examinations were assayed before perfusion and 2 hours after plasma perfusion. Blood pressure, heart rate, respiration and temperature were monitored regularly. Results Perfusion continued for 2 hours. After the perfusion, plasma total bilirubin decreased by 29 %, indirect bilirubin decreased by 26 %, direct bilirubin decreased by 31% （P 〈 0.05）, plasma protein decreased by 7 %, albumin decreased by 9 %, and globulin decreased by 4 % （P 〈 0.05）, but without significant changes in serum K＋, Na＋, Ca2＋, Mg2＋ and Phosphate （P 〉 0.05）. After the perfusion, WBC increased by 2 %, RBC decreased by 1%, and platelet decreased by 6 % （P 〉 0.05）. During the perfusion, heart rate, blood pressure, respiration and body temperature remained stable. Conclusion Plasma perfusion with HB-H-6 resin is an effective and safe approach for the treatment of severe hepatocellular jaundice.

关 键 词：血浆灌流器 树脂 黄疸 

分 类 号：R318.14[医药卫生—生物医学工程]