COMT基因遗传多态性与汉族人白癜风易感性关联分析  

Association between polymorphism of COMT gene and vitiligo susceptibility in Chinese Han population

作　　者：王丹妮[1,2,3,4] 权晟[1,2,3,4] 袁锋[1,2,3,4] 张麟[1,2,3,4] 左先波[1,2,3,4] 孙良丹[1,2,3,4] 杨森[1,2,3,4] 张学军[1,2,3,4] 

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230022 [2]安徽医科大学皮肤病研究所,合肥230032 [3]教育部重要遗传病基因资源利用重点实验室(省部共建),合肥230032 [4]安徽医科大学皮肤性病学系,合肥230032

出　　处：《安徽医科大学学报》2009年第3期302-304,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽医科大学国家创新研究群体科学基金获得者培育计划(编号:GJCXQT-0801)

摘　　要：目的研究汉族人COMT基因多态性与白癜风易感性的相关性。方法应用Illumina 610-Quad芯片在1123例白癜风患者和1227例正常对照中进行全基因组关联分析,选取芯片上覆盖COMT基因的单核苷酸多态性(single nu-cleotide polymorphism,SNP)分型数据,用Plink1.03软件进行分析处理。结果COMT基因上10个SNP位点的等位基因频率在病例组和对照组之间差异无统计学意义(rs1544325,P=0.1802),(rs165722,P=0.1513),(rs165774,P=0.3729),(rs174675,P=0.6802),(rs2239393,P=0.4598),(rs4646312,P=0.4787),(rs4646316,P=0.4427),(rs4680,P=0.0886),(rs5993883,P=0.1819),(rs737866,P=0.1225)。结论COMT基因的10个SNP位点(rs1544325、rs165722、rs165774、rs174675、rs2239393、rs4646312、rs4646316、rs4680、rs5993883、rs737866)可能与汉族人白癜风易感性无关联。Objective To study the relationship between the polymorphism of COMT gene and vitiligo susceptibility in Chinese Han population. Methods The genotyping analysis was done by using the Illumina Human 610-Quad BeadChips in 1 123 cases and 1 227 controls,then we selected genotyping data on COMT gene of SNP. Statistical analysis was performed by the Plink 1.03 software. Results The differences of allele frequencies between eases and controls were not statistically significant （ rs1544325 ,P = 0. 1802）, （ rs165722 ,P = 0. 1513 ）, （ rs165774 ,P = 0. 3729）, （ rs174675, P = 0. 6802）, （ rs2239393, P = 0. 4598 ）, （ rs4646312, P = 0. 4787 ）, （rs4646316, P=0. 4427 ）, （ rs4680, P =0.0886） ,（rs5993883,P =0. 1819）, （rs737866,P =0. 1225）. Conclusion The results suggest that the SNPs rs1544325, rs165722, rs165774, rs174675, rs2239393, rs4646312, rs4646316, rs4680, rs5993883, rs737866 on COMT gene may be not associated with the susceptibility of vitiligo in Chinese Han population.

关 键 词：白癜风 多态性 单核甘酸 

分 类 号：R758.41[医药卫生—皮肤病学与性病学] R394.3[医药卫生—临床医学]