CTLA4基因多态性与汉族人白癜风易感性相关分析  

Association between polymorphism of CTLA4 gene and vitiligo susceptibility in Chinese Han population

作　　者：张麟[1,2,3,4] 袁锋[1,2,3,4] 王丹妮[1,2,3,4] 王培光[1,2,3,4] 孙良丹[1,2,3,4] 张学军[1,2,3,4] 杨森[1,2,3,4] 

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230022 [2]安徽医科大学皮肤病研究所,合肥230032 [3]教育部重要遗传病基因资源利用重点实验室(省部共建),合肥230032 [4]安徽医科大学皮肤性病学系,合肥230032

出　　处：《安徽医科大学学报》2009年第3期305-307,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽医科大学国家创新研究群体科学基金获得者培育计划(编号:GJCXQT-0801)

摘　　要：目的研究汉族人CTLA4基因多态性与白癜风易感性的相关性。方法利用Illumina 610-Quad芯片对1123例白癜风患者和1227例正常对照样本进行基因分型,提取CT-LA4基因的相关分型数据,用Plink1.03软件进行统计分析。结果CTLA4基因上2个SNP位点(rs733618和rs231726)的等位基因频率在病例组和对照组之间的差异无统计学意义(P>0.05)。结论CTLA4基因多态性与汉族人白癜风易感性可能无关联。Objective To study the association between CTLA4 gene and vitiligo in Chinese Han population. Methods The genotyping was done by using the Illumina Human 610-Quad BeadChips in 1 123 cases of vitiligo and 1 227 controls, then we selected genotyping data on CTLA4 gene、 Statistical analysis was performed by the Plink 1.03 software. Results It showed that the differences of 2 SNPs （rs733618 and rs231726） on CTLA4 gene between cases and controls had not statistically significant （ P 〉 0. 05 ）. Conclusion The results suggest that the CTLA4 gene may not be associated with the susceptibility of vitiligo in Chinese Hart population.

关 键 词：白癜风/遗传学 多态性 单核苷酸 

分 类 号：R758.41[医药卫生—皮肤病学与性病学] R394.3[医药卫生—临床医学]