67例次持续非卧床腹膜透析相关腹膜炎致病菌及耐药性分析  

The analysis of 67 cases of CAPD-related peritonitis pathogens and their resistance

作　　者：齐向明[1] 赵珉[1] 张培[1] 郝丽[1] 戴宏[1] 张伯科[1] 

机构地区：[1]安徽医科大学第一附属医院肾脏内科,合肥230022

出　　处：《安徽医科大学学报》2009年第3期393-395,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨持续性非卧床腹透(CAPD)相关性腹膜炎的致病菌及其耐药性。方法回顾性分析67例次CAPD相关性腹膜炎的致病菌及其耐药性。结果34例次培养阳性,培养阳性率达,其中革兰阳性球菌23例次,革兰阴性杆菌8例次,真菌1例次。革兰阳性球菌对头孢唑啉耐药率65.2%,万古霉素为0;革兰阴性杆菌对丁胺卡那耐药率14.3%,庆大霉素为42.9%,而对头孢他啶耐药率也高达42.9%,亚胺培南为14.3%。结论CAPD相关腹膜炎细菌仍然以革兰阳性球菌为多数,致病菌对头孢唑啉和庆大霉素耐药性较高。细菌培养及药敏试验结果对抗生素的选择有指导意义。Objective To investigate the pathogens and their resistance in continuous ambulatory peritoneal dialysis （CAPD） -related peritonitis. Methods Pathogens and their resistance in 67 cases of CAPD-related peritonitis were analyzed retrospectively. Results Thirty four cases were culture positive with a positive rate of 47.8%, including 23 cases with Gram-positive cocci,8 cases with Gram-negative bacilli and 1 case with fungi. Their drug sensitivity was 65.2% of the Gram-positive cocci sensitive to cephazoline and all sensitive to vancomycin; 14. 3% resistant to amikacin; 42.9% resistant to gentamicin; 42.9% resistant to ceftazidime and 14.3 % of Gram-negative bacilli resistant to imipenem. Conclusion Gram-positive cocci are still predominate in CAPD-related bacterial peritonitis. There was increased resistance of gram-positive organisms to cefazolin and gentamicin. Bacterial culture and sensitivity test results guide antibiotic choice.

关 键 词：腹膜透析 持续不卧床/副作用 腹膜炎/微生物学 抗药性 细菌 抗菌药 

分 类 号：R692.5[医药卫生—泌尿科学] R37[医药卫生—外科学]