维库溴铵在急性颅高压气管插管术前的应用  

Application of Vecuronium Bromide for Patients with Acute Intracranial Hypertension Before Endotracheal Intubation

作　　者：李辉[1] 高波[2] 魏嘉[1] 陆健[1] 张传雨[1] 李翔[1] 洪波[1] 

机构地区：[1]安徽省红十字朝阳医院急诊科,安徽淮南232007 [2]安徽省红十字朝阳医院ICU病房

出　　处：《药物流行病学杂志》2009年第3期175-177,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:观察维库溴铵对气管插管术中刺激反应的抑制作用。方法:将颅高压患者41例随机分为对照组20例,术前给予地西泮0.3～0.6mg·kg^(-1),iv,阿托品0.5～1.0mg,iv,利多卡因1mg·kg^(-1),iv,3min后行插管术。治疗组21例,在治疗组用药基础上再用维库溴铵4～8mg iv。观察刺激反应、循环指标、颅内血肿情况。结果:治疗组较对照组,术中术后刺激反应发生率、插管成功率,术中收缩压、氧饱和度、中心静脉压,插管术前后颅内血肿增加量,均有显著差异(P<0.05);死亡率降低差异不显著(P>0.05)。结论:维库溴铵对气管插管术中刺激反应的抑制作用强。Objective： To observe the inhibitory effect of vecuronium bromide on the stimulus-response in the course of endotracheal intubation. Method： 41 patients with increased intracranial pressure were randomly divided into a controlled group （n = 20） and treatment group （n = 21 ）. Vecuronium （4 -8mg, iv） was given to the treatment group in addition to diazepam, atropine and lidocaine that were given to the controlled group. Then the stimulus response, circulatory indicators and intracranial hematoma were observed. Result： The incidence of stimulus-response during and after the operation, achievement ratio of cannula, systolic blood pressure, oxygen saturation and central venous press of the operation,increase of intracranial hematoma before and after the operation were significantly different in the two groups, but the mortality had no remarkable difference between them. Conclusion： The inhibitory effect of vecuronium bromide on the stimulus response in the course of endotracheal intubation is stronger.

关 键 词：维库溴铵 气管插管术 刺激反应 颅高压 急性 脑出血 

分 类 号：R971.8[医药卫生—药品]