喜炎平注射液联合α-2b干扰素治疗婴幼儿轮状病毒肠炎的临床观察  

Clinical study of the effect of Xiyanping injection and IFNα-2b on infantile rotavirus enteritis

作　　者：万琦[1] 鄢素琪[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心中医科,湖北武汉430016

出　　处：《中国医院药学杂志》2009年第11期916-918,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：观察喜炎平注射液联合α-2b干扰素治疗婴幼儿轮状病毒肠炎的疗效。方法：对确诊为轮状病毒肠炎的104例患儿随机分为常规治疗组（n=36）、喜炎平治疗组（n=35）和喜炎平＋干扰素治疗组（n=33）3组，疗程5～7d，比较3组患儿止泻时间、显效率与总有效率。结果：喜炎平＋干扰素组止泻时间较常规组及喜炎平组明显缩短，差异有显著性。治疗总有效率常规组、喜炎平组、喜炎平＋干扰素组分别为41．7％、85．7％、93．9％，喜炙平组、喜炎平＋干扰素组明显优于常规组；喜炎平＋干扰素组总有效率与喜炎平组比较差异无显著性（P〉0．05），但显效率明显高于喜炎平组（P〈0．01）。结论：喜炎平注射液联合α-2b干扰素治疗轮状病毒肠炎疗效较好，值得临床应用。OBJECTIVE To observe the effect of Xiyanping injection combined with interferon α-2b on infantile rotavirus enteritis. METHODS 104 eases with rotavirus enteritis were divided into three groups： conventional group（n = 36）, Xiyanping group （n = 35） and Xiyanping ＋ interferon group（n = 33）. The duration of using drugs was 5-7 days. The following indexes were assessed in three groups： the duration of weaning diarrhea,the percentage of effectiveness of drugs. RESULTS The duration of weaning diarrhea in Xiyanping ＋ interferon group was significantly shorter compared with that of the conventional group and Xiyanping group. The total effective rates of conventional group, Xiyanping group and Xiyanping ＋ interferon group were 41.7%.85.7%,93.9%. The total effective rates of Xiyanping group and Xiyanping ＋ interferon group were significantly higher compared with the conventional group. There was no significant difference between Xiyanping ＋ interferon group and Xiyanping group（P〉0.05）, but the notable effective rates of the former group were significantly higher than that of Xiyanping group（P〈0.01 ）. CONCLUSION Xiyanping injection combined with interferon α-2b in treating infants with rotavirus enteritis is effective.

关 键 词：喜炎平注射液 干扰素 轮状病毒肠炎 婴幼儿 

分 类 号：R969.4[医药卫生—药理学]