无精子症病因分析:实验诊断流程图的应用  

Study on etiology of azoospermia:application of flow chart of laboratory diagnosis

作　　者：黄永汉[1] 杨明[1] 邓天勤[1] 谭兴银[1] 李颖嫦[1] 张海滨[1] 

机构地区：[1]中山大学附属佛山医院佛山市第一人民医院泌尿外科,佛山528000

出　　处：《中国男科学杂志》2009年第5期28-31,共4页Chinese Journal of Andrology

基　　金：广东省科技厅基金资助项目(编号:2006B35930009);佛山市科技局研究项目(编号:200508044)

摘　　要：目的应用无精子症实验诊断流程图,探讨实验诊断在无精子症病因分析中的意义。方法对672例无精子患者按无精子症实验诊断流程图进行精液常规检查和精浆生化检测,精液脱落细胞计数,血清性激素或抑制素B测定,染色体核型分析或基因检测(AZF),必要时细针经皮睾丸穿刺活检等检查,同时结合病史及体格检查判断无精子症的病因。结果睾丸前病因37例(5.5%),睾丸病因284例(42.3%),睾丸后病因262例(39.0%),特发性无精子症89例(13.2%)。结论无精子症实验诊断流程图在病因诊断中起到规范作用,有利于指导治疗。Objective To explore the clinical significance of flow chart of laboratory diagnosis in the etiology of azoospermia. Methods Based on the flow chart of laboratory diagnosis for azoospermia, Semen routine test, biochemistry analysis of seminal plasma, spermatogenic ceils counting, detection of serum sex hormone and inhibin B,chromosomes karyotype or AZF gene analysis were performed in all 672 cases with azoospermia, Percutaneous needle testicular biopsy was done in some patients for final diagnosis. History and physical examination as assistant evidence to judge the cause of azoospermia. Results The pretesticular etiology for azoospermia account for 5.5%, testicualar 42.3%, posttesticular 38.9%, idiopathic azoospermia 13.2%. Conclusion The flow chart of laboratory diagnosis for azoospermia might play a role in etiology analysis and treatment of azoospermia.

关 键 词：少精子症 实验室技术和方法 果糖 中性 Α-葡糖苷酶 弹性硬蛋白酶 

分 类 号：R698.2[医药卫生—泌尿科学]