砂仁、藿香、苍术挥发油对士的宁体外经皮渗透的影响  

The Effects of Volatile Oil of Frustus Amomi,Wrinked Gianthyssop Herb and Rhizoma Atractylodis on Percutaneous Penetration of Strychnine in Vitro

作　　者：蒋艳芳[1] 马云淑[1] 杨志远[1] 沈留英[1] 张毅[1] 

机构地区：[1]云南中医学院中药学院,云南昆明650500

出　　处：《云南中医学院学报》2009年第3期8-12,共5页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(NO:30560187)

摘　　要：目的:考察砂仁、藿香、苍术挥发油对士的宁体外经皮渗透的影响。方法:采用改良Franz扩散池法,以小鼠皮肤为透皮屏障,采用紫外分光光度法测定模型药士的宁的含量。以氮酮为对照,分别考察1%,3%,5%,7%、10%的砂仁、藿香、苍术挥发油对士的宁的促渗效果。结果:5%砂仁挥发油,5%藿香挥发油,1%苍术挥发油与3%氮酮对士的宁的促渗效果最好,对士的宁(6.6230 mg/mL)12h的平均累积渗透量(Q12,mg/cm2)分别为2.1487,2.3579,2.2450,2.3520;增渗倍数分别为1.0133,1.1148,1.1934,1.0625。结论:5%砂仁,5%藿香,1%苍术挥发油对士的宁有一定的促透作用。Objective ： To investigate the effects of volatile oil of Frustus Amomi （ FA ）, volatile oil of Wrinked Gianthyssop Herb （WGH） and volatile oil of Rhizoma Atractylodis （RA） on percutaneous penetration of strychnine through mouse skin in vitro. Methods： By using an improved Franz diffusion cells , the effects of these 3 volatile oils on the percutaneous penetration of strychnine were observed and compared with Azone, and the content of strychnine was determined by ultraviolet spectrophotometry. Results： 5% （v/v） volatile oil of FA and WGH, 1% （v/v） volatile oil of RA and 3% （v/v） Azone had best enhancing effects on the permeation of strychnine in Vitro. The average cumulative doses of skin permeation of strychnine （6. 6230 mg/ml） for 12 hours （Q12, mg/cm^2） were 2. 1487, 2. 3579, 2. 2450 and 2. 3520mg/cm^2 respectively and the multiple of enhancement werel. 0133, 1. 1148, 1. 1934 and 1. 0625 respectively. Conclusion： The volatile oil of 5% FA , 5% WGH and 1% RA possesed certain effect of the permeation enhancement of strychnine in vitro.

关 键 词：促渗剂 士的宁 砂仁挥发油 藿香挥发油 苍术挥发油 

分 类 号：R285.5[医药卫生—中药学]