不同旋光度PLGA的制备及其结晶性能研究  

Preparaion of PLGA with Different Optical Rotation and Their Crystallization Behavior

作　　者：熊左春[1,2] 陈栋梁[1] 李庆[1] 黄冬玲[1] 熊成东[1] 

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院研究生院,北京100039

出　　处：《合成化学》2009年第3期292-295,共4页Chinese Journal of Synthetic Chemistry

摘　　要：以消旋丙交酯、左旋丙交酯和乙交酯为原料,以辛酸亚锡为引发剂,在高真空条件下本体熔融开环聚合,制得一系列不同旋光度的丙交酯乙交酯共聚物(PLGA),其结构经1H NMR,IR,XRD和DSC表征。并采用DSC研究了PLGA的熔体结晶行为,结果表明其结晶性能随其旋光度的减少而显著降低,甚至不结晶。A series of poly （lactide-co-glycolide） （PLGA） with different optical rotation were prepared from glycolide, DL-lactide and L-lactide by ring-opening copolymerization in noumenon molten state using stannous octoate as an initiator under high vacuum. The structures were characterized by ^1H NMR, IR, XRD and DSC. The melt-crystalhzation behavior of PLGA has been investigated by DSC. The results show that as the optical rotation of PLGA decreases, their crystaUizability decreases significantly, even when no crystallize has occurred.

关 键 词：丙交酯 乙交酯 共聚物 熔融聚合 

分 类 号：O633.14[理学—高分子化学]