新生儿红细胞免疫功能测定及影响因素的研究  

Determination of the erythrocyte immunological function and its influential factors in neonates

作　　者：林丽星[1] 杨梅[1] 张青玉 康曦光[1] 

机构地区：[1]兰州大学第一医院儿科,甘肃兰州730000 [2]兰州市城关区中医骨伤科医院儿科,甘肃兰州730000

出　　处：《中国儿童保健杂志》2009年第3期275-277,共3页Chinese Journal of Child Health Care

基　　金：甘肃省自然科学基金项目(3ZS061-A25-086)

摘　　要：【目的】了解新生儿红细胞免疫功能变化,观察围产因素对新生儿红细胞免疫功能的影响。【方法】采用红细胞酵母花环法测定新生儿红细胞C3b受体花环率(the adherence rate of complement 3b-receptor onthe surface ofred blood cell,RBC-C3bRR)和红细胞免疫复合物受体花环率(the i mmune complex adherence rate of red blood cell,RBC-ICR)。【结果】①104例正常新生儿的RBC-C3bRR为:16.80±1.56;RBC-ICR为:5.72±1.63。母婴配对分析表明产妇的RBC-ICR与新生儿的RBC-ICR具有高度正相关(P<0.01);②52例高胆红素血症新生儿RBC-C3bRR为:13.59±1.55,RBC-ICR为:4.47±1.37,低于正常新生儿(P<0.01);③73例缺氧缺血性脑病新生儿RBC-C3bRR为:13.37±1.68;RBC-ICR为:4.39±1.50;低于正常新生儿(P<0.01);④新生儿RBC-C3bRR和RBC-C3bRR与胎龄、日龄、性别、羊水、胎盘、脐带、分娩方式等因素无相关性(P>0.05);与出生体重、喂养方式有明显相关性。【结论】新生儿的红细胞免疫功能已相对成熟,但易受多种因素影响。新生儿高胆红素血症及缺氧缺血性脑病红细胞免疫功能降低。[Objective] To study the change of erythrocyte immune function in neonates and observe the influence of various obstetric factors on neonatal erythrocyte immune function. [Methods] The adherence rate of complement 3b-receptor on the surface of red blood cell（RBC-C3bRR） and the immune complex adherence rate of red blood cell（RBC-ICR） were detected with erythrocyte saceha-romycete rosettet test. [Results] ①The levels of RBC-C3bRR and RBC-ICR were 16. 80±1.56 and 5.72± 1.63 respectively in 104 normal neonates. There was a significantly positive correlation in RBCICR levels between neonates and their mothers（P〈0.01）. ②The levels of RBC-C3bRR （13.59±1.55） and RBC-ICR（4.47±1.37） of 52 neonates with hyperbilirubinemia were all lower than control group（P〈0.01）. ③The levels of RBC-C3bRR （13.37±1.68） and RBC-ICR （4.39±1.50） in 73 neonates with hypoxic-ischemic encephalopathy（HIE） were all lower than control group（P〈0.01）. ④ There were no correlation between RBC-C3bRR, RBC-C3bRR and various factors, such as gestation age, day age, gender, amniotic fluid, placenta, umbilical cord, presentation labor （P〉 0. 05 ）, but there were significant correlation between, RBC-C3bRR and birth weight, feeding patterns. [Conclusions] Erythrocyte immune function in newborns has relatively matured, but it can be easily influenced by many factors. There is decrease in erythrocyte immune function in newborns with hyperbilirubinemia and hypoxic-ischemic encephalopathy.

关 键 词：红细胞 免疫性 缺氧缺血性脑病 高胆红素 新生儿 

分 类 号：R722.1[医药卫生—儿科]