缺血修饰清蛋白在急性冠状动脉综合征早期诊断中的临床意义  

Clinical Significance of Ischemia Modified Albumin in Early Diagnosis of Acute Coronary Syndromes

作　　者：肖路延[1] 王萌[1] 唐志毅[1] 郭健[1] 

机构地区：[1]卫生部北京医院检验科,北京100730

出　　处：《现代检验医学杂志》2009年第3期154-157,共4页Journal of Modern Laboratory Medicine

摘　　要：目的探讨缺血修饰清蛋白（ischemia modified albumin，IMA）检测在急性冠脉综合征（acute coronary syndromes，ACS）早期诊断中的应用价值。方法57例确诊ACS患者在发病后的入院即刻，2，4，6，12h采集静脉血分别检测血清中IMA、肌红蛋白（MYO）、肌酸激酶同工酶MB质量（CK—MB mass）、肌钙蛋白I（cTnI）的浓度，另选35例健康体检者做正常对照组，将测得的结果进行比较，以评价IMA对ACS诊断的临床价值。结果ACS患者中IMA水平于胸痛发作后入院即刻略有升高，但与对照组比较差异无统计学显著性意义（P〉0．1），2h已经明显升高，4h仍持续增高，且均明显高于正常对照组（P〈0．05），6h开始下降并逐渐回到基线水平，而MYO在发病后2h开始升高，CK—MB mass，cTnI水平则在胸痛发作4～6h开始升高。结论IMA对ACS的早期诊断具有较高的敏感度，是一种较理想的ACS早期诊断指标。Objective To research the clinical significance of IMA in early diagnosis of ACS. Methods The serum concentrations of IMA,MYO,CK-MB mass and cTnI were measured in 57 ACS patients on admission,at 2,4,6 and 12 hours after chest pain onset ,elected another 35 healthy physical examinations as control group,and their results were compared to evaluate the clinical value of IMA in the early diagnosis of ACS. Results Except on admission,serum levels of IMA were obviously elevated and reached peak at 2 hours and even higher at 4： hours after chest pain onset. IMA levels started to returned the baseline at 6 hours. Serum levels of IMA were obviously higher than the normal control group（P〈0. 05）. Serum levels of MYO started to elevate obviously at 2-4 hours after chest pain onset,but CK-MB mass and cTnI started to elevate at 4-6 hours and obviously at 12 hours after chest pain onset. Conclusion IMA has higher sensitivity in early phase of ACS,and it can be an ideal marker in the early diagnosis of ACS.

关 键 词：缺血修饰清蛋白(IMA) 急性冠脉综合征(ACS) 肌红蛋白(MYO) 肌钙蛋白I(cTnI) 

分 类 号：R541.4[医药卫生—心血管疾病] R446.112[医药卫生—内科学]