抗SmD1抗体在诊断系统性红斑狼疮中的意义  

Significance of Anti-SmD1 Antibody in the Diagnosis of Systemic Lupus Erythematosus

作　　者：孙乐栋[1] 钟彩梅[1] 贺凤姣[1] 曾抗[1] 周再高[1] 黄良[1] 

机构地区：[1]南方医科大学南方医院皮肤科,广东广州510515

出　　处：《中国皮肤性病学杂志》2009年第6期330-331,共2页The Chinese Journal of Dermatovenereology

基　　金：广东省科技计划项目(2003C32720);南方医院新技术新业务课题(2006004)

摘　　要：目的了解抗SmD1抗体在诊断系统性红斑狼疮(SLE)中的特异性和感敏性,探讨其在SLE诊断中的意义。方法取120例SLE患者和230例非SLE患者的血清,并同时进行抗核抗体(间接免疫荧光法)、抗Sm抗体(免疫斑点法)、抗DNA抗体及抗SmD1抗体(免疫印迹法)检测,统计分析其对SLE患者诊断的特异性与敏感性。结果SLE患者抗SmD1抗体的敏感性为69.17%,特异性为97.82%。结论抗SmD1抗体特异性和敏感性均较高,可作为诊断SLE的参考指标,对SLE的诊断具有重要意义。Objective To investigate the significance of anti-SmD1 antibody in the diagnosis of systemic lupus erythematosus （SLE）. Methods Serum samples of 120 patients with SLE and 230 cases without SLE were tested to detection of antinuclear antibody, anti-dsDNA antibody, anti-Sm antibody and anti-SmD1 antibody, respectively. Results The sensitivity of anti-StuD1 antibody were 69.17% and the specificity was 97.82%. Conclusion Detection of anti-StuD1 antibody had both high sensitivity and specificity in diagnosis of SLE. The determination of anti-SmD1 antibody can improve the sensitivity and efficiency in diagnosis of SLE.

关 键 词：抗SMD1抗体 红斑狼疮 系统性 自身抗体 

分 类 号：R593.241[医药卫生—内科学]