谷胱甘肽S-转肽酶基因多态性与动脉粥样硬化发病机制的研究  

Advances on the Study of Glutathione S-Transferase Genetic Polymorphisms in Atherosclerosis Disease

作　　者：唐建金[1] 王连生[1] 

机构地区：[1]南京医科大学第一附属医院心脏科,210029

出　　处：《国际遗传学杂志》2009年第3期225-229,共5页International Journal of Genetics

摘　　要：既往研究已表明谷胱甘肽S-转肽酶（GSTs）存在基因多态性，这种突变可增加人体对癌源性物质及炎症性疾病的敏感性。近年的研究结果提示GSTs基因多态性与动脉粥样硬化密切相关，这种相关性使我们从分子水平上探讨动脉粥样硬化的发病机制，从而达到基于个体基因型采取预防及治疗措施。Glutathione S-transferase gene exhibits genetic polymorphisms, and this variation can in- crease the susceptibility to carcinogenesis and inflammatory disease. Recent research suggests the gene polymorphism of glutathione S-transferase is associated with atherosclerosis. The study of this relationship and consideration of the molecular aspects of the causes of atherosclerosis should lead to new approaches to the prevention and clinical treatment of atheroscierosis according to individual genotypes.

关 键 词：谷胱甘肽S-转肽酶基因多态性 动脉粥样硬化 基因-环境交互作用 

分 类 号：R54[医药卫生—心血管疾病]