高致病性猪繁殖与呼吸障碍综合征病毒感染猪主要脏器的超微结构变化  

Ultrastructural Changes of Organs from Pig Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

作　　者：曹剑波[1] 李彬[2] 陈焕春[2] 肖少波[2] 

机构地区：[1]华中农业大学公共电镜平台,武汉430070 [2]华中农业大学动物医学院,武汉430070

出　　处：《华中农业大学学报》2009年第3期330-333,共4页Journal of Huazhong Agricultural University

基　　金：国家科技支撑计划项目(2007BAD86B02/06)资助

摘　　要：对高致病性猪繁殖与呼吸障碍综合征病毒(HP-PRRSV)人工感染的成年猪脏器进行透射电子显微镜观察,结果发现,肺部组织细胞病变最严重,部分毛细血管破裂,毛细血管内皮细胞裂解,肺泡巨噬细胞线粒体嵴肿胀严重;脑部组织神经元细胞凋亡和胶质细胞坏死;肾脏和淋巴结组织中均出现病毒的复制和线粒体嵴的肿胀。该结果为阐明HP-PRRSV的致病机理提供了实验依据。Transmission electron microscopy （TEM） was employed for the organs from pigs infected with high pathogenic porcine reproductive and respiratory syndrome virus （HP-PRRSV）. Results showed that lung tissues have severe pathology including capillary vessels disruption, endothelial cells lysis and the crista of pulmonary macrophages swelling. There are apoptosis of neurons and necrosis of neuroglial cells in brain tissues. HP-PRRSV replicates in kidney and lymph and induces the crista swelling. These observations of the ultrastructural changes in the organs of HP-PRRSV infected pigs may facilitate understanding the mechanisms of HP-PRRSV infection and pathogenesis.

关 键 词：高致病性猪繁殖与呼吸障碍综合征病毒 超微结构 猪 

分 类 号：S852.65[农业科学—基础兽医学]