胸腺五肽多囊脂质体的制备及体外释放的考察  

Preparation and drug release in vitro of Thymopentin multivesicular liposomes

作　　者：左佼[1] 赵越[1] 张志荣[1] 李艳贞[1] 石三军[1] 龚涛[1] 

机构地区：[1]四川大学华西药学院靶向药物与传递系统教育部重点实验室,四川成都610041

出　　处：《华西药学杂志》2009年第3期229-231,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的制备胸腺五肽多囊脂质体,并考察其包封率和体外释放情况。方法采用复乳法制备胸腺五肽多囊脂质体,并用单因素、正交实验对处方进行优化。结果制备的胸腺五肽多囊脂质体的外观圆整均匀,形态良好,包封率为80.15%±3%。体外释放的零级动力学方程为:Y=0.536X+20.431(r2=0.9814),132 h的累积释放率为92.01%。结论复乳法制备的胸腺五肽多囊脂质体的工艺可行,包封率较高,有明显的缓释特征。OBJECTIVE To prepare Thymopentin muhivesicular liposomes and investigate the encapsulation efficiency and drug release profile in vitro. METHODS Thymopentin multivesicular liposomes were prepared by double emulsion process, then, the formulation was optimized by single factor and orthogonal design experiments. RESULTS Thymopentin muhivesieular liposomes seemed round,well- distributed and had good appearances. The encapsulation efficiency was 80.15% ± 3%. The release kinetics was characterized by zero - order equation ： Y = 0. 536X ＋ 20.431 （ r^2 = 0.9814）, and the cumulative release of multivesecular was 92.01% within 132 h. CONCLUSION It is effective to use double emulsion method, and Thymopentin muhivesecular liposomes show high encapsulation efficiencies and significant sustained release properties.

关 键 词：胸腺五肽 多囊脂质体 包封率 体外释放 

分 类 号：R94[医药卫生—药剂学]