九香止痛丸的鉴别及木香烃内酯和去氢木香烃内酯的测定  

Identification of Jiuxiang Zhitong pill and determination of costunolide and dehydrocostunolide

作　　者：余晓琴[1] 李萍[1] 董林[1] 车晓彦[1] 李欧 

机构地区：[1]四川省食品药品检验所,四川成都610036 [2]成都九芝堂金鼎药业有限公司,四川成都610051

出　　处：《华西药学杂志》2009年第3期312-313,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的建立九香止痛丸的质量标准。方法采用TLC法鉴别降香、丁香及乳香；HPLC法测定方中川木香、木香的含量。结果TLC鉴别斑点明显；木香烃内酯的进样量0．112—5．600ug、去氢木香内酯的进样量0．104～5．200ug与峰面积的线性关系均良好。木香烃内酯的平均加样回收率为98．7％，RSD=2．2％（n=6）；去氢木香内酯的平均回心率为99．6％，RSD：2．2％（n=6）。结论所建方法专属性强、重复性好，可用于九香止痛丸的质量控制。OBJECTIVE To improve the quality standard of Jiuxiang Zhitong pills. METHODS Lignum Dalbergiae odoriferae, Flos Caryophyllata and Frankincense were identified by TLC. The content of Radix Vladimiriae and Putchuck was determined by HPLC. RESULTS The developed TLC spots was quite clear. The calibration curve of costunolide was linear within 0. 104 - 5. 200 pug. And the calibration curve of dehydrocostunolide was linear within 0.112 -5. 600 pug. The average recoveries of costunolide and dehydroeostunolide were 98.7 % with RSD of 2.2% （ n = 6） and 99.6% with RSD of 2.2 % （ n = 6）, respectively. CONCLUSION The established methods are exclusive , reproducible and suitable for the quality control of Jiuxiang Zhitong pills.

关 键 词：九香止痛丸 质量标准 薄层色谱法 高效液相色谱法 木香烃内酯 去氢木香烃内酯 

分 类 号：R917[医药卫生—药物分析学]