大鼠丘脑肽能神经元的分布  

DISTRIBUTION OF PEPTIDERGIC NEURONS IN THE THALAMUS OF THE RAT

作　　者：包新民[1] 舒斯云[1] 

机构地区：[1]第四军医大学神经生物研究室,西安710032

出　　处：《解剖学报》1990年第4期387-393,共7页Acta Anatomica Sinica

摘　　要：用免疫组织化学方法研究了胆囊收缩素(CCK)、血管活性肠肽(VIP)、P物质(SP)、神经降压素(NT)、甘丙肽(GAL)、降钙素基因相关肽(CGRP)、促皮质素释放因子(CRF)和促甲状腺素释放激素(TRH)等8种肽能神经元在大鼠丘脑中的分布。免疫阳性胞体及纤维终末主要位于丘脑的中线核、板内核、后核和缰核,丘脑前核、腹侧核及网状核中较少。不同肽能神经元在丘脑中的分布部位不同。中线核及板内核中有较多的SP、NT及GAL阳性胞体以及所有上述8种肽能神经元的阳性终末,后核群中CCK和NT及CGRP、CRF阳性胞体较多,缰核中可见VIP、SP、NT、GAL及CRF阳性胞体以及除CGRP以外的其余7种阳性终末。本文观察到的免疫阳性结果,尤其是阳性终末的分布,要比文献报道的广泛,有些CCK、VIP、NT、GAL、CGRP及TRH阳性胞体或终末在丘脑中的分布尚未见报道。Using immunohistochemical method, the distribution of eight kinds of peptidergic neurons, i. e. cholecystokinin(CCK),vasoactive intestinal polypeptide (VIP), substance P(SP), neurotensin (NT), galanin (GAL), calcitonin gene-related peptide (CGRP), corticotropin-releasing factor(CRF) and thyrotropin-releasing hormone(TRH), of the thalamus in the rat was investigated. Immunoreactive cell bodies and fiber terminals were mainly located in the midline nuclei, intralaminar nuclei, habenular nucleus and posterior nuclei of the thalamus, but a few of positive structures in the anterior nuclei, ventral nuclei and reticular nucleus were also found. The distribution of different peptidergic neurons in the thalamus was different from each other. A large quantity of SP-, NT- and GAL- like cell bodies and all of above-mentioned eight peptidergic fiber terminals were observed in the midline nuclei and intralaminar nuclei. More CCK and CGRP positive cell bodies were seen in the posterior nuclei. Some VIP, SP, NT, GAL and CRF positive cell bodies and all kinds of the positive terminals, except CGRP, were found in the habenular nucleus. The immunoreactive structures which were found in present study, particularly the distribution of positive terminals, were more widely than those were reported. The distribution of some CCK, VIP, NT, GAL, CGRP and TRH positive cell bodies and terminals in the thalamus have not been reported previously.

关 键 词：丘脑 肽能神经元 免疫组织化学 

分 类 号：R338.24[医药卫生—人体生理学]