脑源性神经营养因子在PCOS患者卵泡发育中的作用  

Effect of brain-derived neurotrophic factor on ovarian follicle development in patients with polycystic ovarian syndrome

作　　者：葛亚娟[1] 程利南[2] 陈炳锦[1] 孙晓溪[2] 王龙武[1] 

机构地区：[1]复旦大学附属上海市第五人民医院,上海200240 [2]中国福利会国际和平妇幼保健院

出　　处：《中国妇幼保健》2009年第18期2482-2484,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨脑源性神经营养因子(BDNF)在卵泡发育和卵母细胞成熟过程中的作用。方法:采用ELISA法检测PCOS卵泡液中BDNF含量。结果:所有61例标本均检测出BDNF。IVM-PCOS组BDNF最低205 pg/ml、最高804 pg/ml,平均512 pg/ml;IVF-PCOS组BDNF最低540 pg/ml、最高1 303 pg/ml,平均888 pg/ml;IVF-Normal组BDNF最低368 pg/ml、最高1 089 pg/ml,平均734 pg/ml。三组间比较或两两比较差异均有统计学意义(P<0.001)。BDNF水平以IVF-PCOS组最高、IVF-Normal组次之、IVM-PCOS组最低。结论:成熟卵泡颗粒细胞存在BDNF的表达,BDNF可能与卵泡成熟及PCOS的发生发展有关。Objective： To explore the effect of brain -derived neurotrophic factor （BDNF） on ovarian follicle development in patients with polycystic ovarian syndrome （PCOS） . Methods： The levels of BDNF in follicular fluids of patients with PCOS were detected by enzyme linked immunosorbent assay. Results： The levels of BDNF were detected in all the 61 cases. The level of BDNF in IVM - PCOS group was 205 - 804 pg/ml, 512 pg/ml on average; the level of BDNF in IVF - PCOS group was 540 -1303 pg/ml, 888 pg/ml on average ; the level of BDNF in IVF - Normal group was 368 - 1 089 pg/ml, 734 pg/ml on average, there was significant difference among three groups （ P 〈 0. 001 ） . The highest BDNF level was IVF - PCOS group, the second was IVF - Normal group, the last was IVM - PCOS group. Conclusion ： BDNF expresses in mature follicular ceils, which is probably related to follicle maturation and pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 脑源性神经营养因子 酶联免疫吸附法 

分 类 号：R711.75[医药卫生—妇产科学]