高效液相色谱氮杂冠醚键合固定相的合成及性能研究  

Preparation and Evaluation of Aza Crown Ether Bonded Silica for High performance Liquid Chromatography

作　　者：冯钰锜[1] 龚银汉[1] 达世禄 

机构地区：[1]武汉大学化学系

出　　处：《高等学校化学学报》1998年第5期720-722,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：我们曾用γ－氯丙基键合硅胶（ＣＰＳ），在氢化钠（ＮａＨ）作用下合成了３－（氮杂－１８－冠－６）丙基键合固定相（ＢＣＰ）［１］．该固定相对碱基、核苷酸、硝基苯酚等有较好的分离选择性，但由于ＮａＨ对硅胶基质腐蚀作用较大，导致ＢＣＰ柱效及渗透性较低．本文采...Aza 18 crown 6)propylsily bonded silica stationary phase for high performance liquid chromatography was prepared via two step solid liquid reaction as follows: porous silica(5￣7 μm) was activated using γ chloropropyl triethoxysilane, then reacted with sodium secondary amine salt of monoaza 18 crown 6. The bonded stationary phase shows a good complexing ability with sodium and potassium ions. The chromatographic behavior of disubstituted benzenes and amino acids was investigated on the bonded stationary phase with various mobile phases.

关 键 词：高效液相色谱 键合硅胶 固定相 氮杂冠醚 

分 类 号：O657.720.3[理学—分析化学]