微乳中复凝聚法制备壳聚糖-明胶纳米胶囊  

Nanocapsules Preparation by Complex Coacervation in Microemulsion With Chitosan-gelatin

作　　者：薛超[1] 朱银燕[1] 安学勤[1] 纽少晴[1] 李文龙[1] 王玲[1] 

机构地区：[1]南京师范大学化学与环境科学学院,江苏省生物功能材料重点实验室,江苏南京210097

出　　处：《南京师大学报（自然科学版）》2009年第2期69-72,共4页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：国家自然科学基金(20673059);江苏省普通高校自然科学研究计划(07KJD150099)资助项目

摘　　要：以明胶和壳聚糖作为包裹材料，在O／W型微乳液模板中，用复凝聚的方法制备纳米胶囊，考察了影响合成纳米胶囊的主要因素，并进行了分析．结果表明，本实验采用的在微乳中复凝聚法合成了分散性好、粒度均匀、粒径200—400nm的球形纳米胶囊．制备了尼莫地平（NMP）纳米胶囊，得到包封率达到90％、粒径500～800nm的载药纳米胶囊．Nanocapsules were prepared in O/W microemulsion by complex coacervation of chitosan and gelatin. The preparation conditions of polymeric nanocapsules were analyzed. The results demonstrate that the nanocapsules with size of 200 -400 nm are spherical with uniform particle diameter distribution. Nanoeapsule drug carrying NMP was prepared, and the nanoeapsules with size of 500 - 800 mn have entrapment efficiency of 90%.

关 键 词：微乳液 复凝聚 壳聚糖 明胶 纳米胶囊 尼莫地平 

分 类 号：O648[理学—物理化学]