输注硫酸镁减少术后病人自控镇痛曲马朵用药量  

Application of a Small Dose of Magnesium Sulfate Combined with Tramadol for Intravenous Postperative Aanalgesia

作　　者：张智艳[1] 田谋利[2] 陈普望[3] 

机构地区：[1]解放军第二军医大学长海医院药剂科,上海200433 [2]解放军第二军医大学长征医院麻醉科,上海200003 [3]解放军西藏军区总医院麻醉科,西藏拉萨850007

出　　处：《临床军医杂志》2009年第3期447-448,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨静脉滴注硫酸镁与术后PCA镇痛效果间的关系。方法采用随机、双盲方法将40例择期上腹部手术病人分为两组,分别静脉注射硫酸镁和生理盐水。并对两组间术后VSA分数、术后24h曲马朵用量、镇痛效果与不良反应进行分析比较。结果镁离子组术后24h曲马朵用量明显低于对照组,两组间镇痛效果及不良反应发生率无明显差异。结论术后行PCA时加用硫酸镁可加强PCA镇痛药的效果,减少术后PCA镇痛药用量。Objective To investigate the relationship between intravenous drip infusion of magnesium sulfate and dose of analgesia drug in PCA. Methods Forty patients with upper abdominal operation were randomly divided in two groups by double-blind method. Mg group was infused with magnesium sulfate and control group was infused with saline. The results of VSA score, dose of tramadol in the first 24 hours after operation, level of consciousness and hemodynamic changes were analyzed. Results There was a significant decrease using dose of tramadol in the first 24 hours after operation in Mg group compared with control group. The analgesic effect and the incidence of adverse reactions between two groups have no significant diference. Conclusion This study demonstrates that infusion of magnesium sulfate can reduce the consumption dose of analgesia drug in PCA. The analgesic effect of this method is better than that of tramadol alone.

关 键 词：硫酸镁 曲马朵 自控镇痛 

分 类 号：R971[医药卫生—药品]