轻稀土对小鼠肺腺癌的抑制作用  

Inhibiting Effect of Light Rare Earth on Pulmonary Adenomas

作　　者：栗建林[1] 张丽帼[1] 刘建中[1] 王丽萍[1] 王宗惠 吴卫东[1] 纪云晶 

机构地区：[1]北京市劳动卫生职业病防治研究所

出　　处：《中国稀土学报》1998年第2期184-187,共4页Journal of the Chinese Society of Rare Earths

摘　　要：小鼠分别饮用１％、０２５％、００６２５％的轻稀土（ＬＲＥ）水溶液，１０ｄ后一次腹腔给予致癌剂氨基甲酸乙酯（ｉｐ），继续饮用稀土水溶液１１０ｄ，肺腺癌发率比非饮用稀土小鼠降低１１６％～３１３％（Ｐ＜００５），平均发瘤数低３５５％～５８０％。并明显激活天然杀伤细胞（ＮＫ细胞）的活力４６％～８５％，提高超氧化物歧化酶（ＳＯＤ）活性，降低脂质过氧化物（ＬＰＯ）含量，抑制温石棉诱导巨噬细胞（ＡＭ）产生超氧阴离子（·Ｏ－２）、羟自由基（·ＯＨ）。The mice were fed watercantaining light rare earth(LRE) of 10%, 025%, 00625% before they were given urethan(ip) once, then they were fed water containing the same LRE doses continuously for 110 d. The results showed that LRE could inhibit the incident of lung tumor by 116%～313% and decreas the average number of adenomas per mouse by 357%～580%(P<005, P<001) and increas 46%～85% of ability of natural kill(NK) cell. The activity of superoxide dismutase(SOD) risen and the content of lipid peroxidation(LPO) reduced in the body of mice as compared with the group of urethantreated mice without feeding RE were abserved. LRE could also supress chrysotileinduced generation of hydroxyl radical and superoxide anion from alveolar macrophages.

关 键 词：稀土 小鼠肺癌 NK细胞 肺腺癌 肺癌 治疗 抑制 

分 类 号：R979.1[医药卫生—药品]