抗癌新药安吖啶的近红外拉曼光谱及近红外表面增强拉曼光谱的研究  

STUDY ON THE NIRRAMAN SPECTRA AND NIRSERS SPECTRA OF AMSACRINE

作　　者：田惠军[1,2] 刘炳玉[1,2] 宋占军[1,2] 沈世杰[1,2] 韩纠缦[1,2] 方炎[1,2] 

机构地区：[1]军事医学科学院国家生物医学分析中心 [2]首都师范大学

出　　处：《光谱学与光谱分析》1998年第3期289-292,共4页Spectroscopy and Spectral Analysis

摘　　要：采用近红外表面增强拉曼光谱（ＮＩＲＳＥＲＳ）技术对抗癌新药安吖啶的结构进行了研究。结果表明，ＮＩＲＳＥＲＳ的增强因子为１０４量级，与安吖啶的固体拉曼光谱对比，该技术可以给出安吖啶在极低浓度和接近其真实应用环境下的结构特性及动力学行为的更多信息。The near infrared surfaceenhanced Raman spectra (NIRSERS) of amsacrine,an anticancer agent,on silver collids were recored with high quality.The NIRSERS enhancement factor is up to 104 magnitude.In comparison with the near infrared Raman(NIRRaman) spectra of solid amsacrine,more information of vibrational structures of amsacrine molecules at low concentration and almost in its practical application environment,can be given by the NIRSERS.The enhancement mechanism is associated with the adsorption of acridyl ring and sulfonyl on silver surface.

关 键 词：安吖啶 近红外拉曼光谱 结构 SERS 分析 

分 类 号：R979.1[医药卫生—药品]