一维多重接力COSY和选择性远程DEPT核磁共振技术在新分子骨架生物碱结构测定和谱峰归属研究中的应用  

Structural Determination and Spectral Assignment of an Alkaloid with a Novel Skeleton by Selective Long-Range DEPT and ID Multiple Relay COSY NMR Techniques

作　　者：缪振春[1] 邓京振[2] 赵守训[2] 冯锐[1] 杜泽涵[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]中国药科大学中草药化学研究室,南京210009

出　　处：《有机化学》1998年第3期243-247,共5页Chinese Journal of Organic Chemistry

摘　　要：自防已科千金藤根中分得一个新型分子骨架的四氢异喹林类生物碱—excentricine(1)。本工作采用一维多重接力COSY和选择性远程DEPT核磁共振新技术成功地确定谱峰归属,鉴别和连结被季碳和杂原子分割开的自旋体系,测定了其结构。A novel skeleton alkaloid, excentricine, was isolated from the roots of stephaniaexcentrica. The recent introduced selective long - range DEPT and ID multiple relay COSY NMR techniques have been successfully used to identify and to connect spin systems separated by quaternary carbons and heterotoms and total assignment of 1H and 13C NMR spectra were achived. Its structure has been elucidated as 1.

关 键 词：四氢异喹林类 生物碱 COSY 结构 NMR 千金藤 

分 类 号：O629.3[理学—有机化学]